{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:28:30Z","timestamp":1782523710692,"version":"3.54.5"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[1991,7,1]],"date-time":"1991-07-01T00:00:00Z","timestamp":678326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:p>We compared the safety and efficacy of a single 400-mg dose of ofloxacin, ofloxacin (200 mg) once daily for 3 days, and trimethoprim-sulfamethoxazole (160:800 mg) twice daily for 7 days for the treatment of acute uncomplicated cystitis (urinary tract infection [UTI]) in women. At 5 weeks posttreatment, 35 (81%) of 43 patients treated with single-dose ofloxacin, 40 (89%) of 45 treated with 3 days of ofloxacin, and 41 (98%) of 42 treated with trimethoprim-sulfamethoxazole were cured (P = 0.03, single-dose ofloxacin group versus trimethoprim-sulfamethoxazole group). Retreatment for symptomatic recurrent UTI was given to 7 (16%) of 43 patients initially treated with single-dose ofloxacin, 3 (7%) of 45 patients treated with 3 days of ofloxacin, and 0 of 42 patients treated with trimethoprim-sulfamethoxazole (P = 0.01, single-dose ofloxacin group versus trimethoprim-sulfamethoxazole group). There was a trend in each of the three treatment groups toward an association between persistent or recurrent episodes of significant bacteriuria and a history of UTI in the past year and with diaphragm use. Ofloxacin was more effective than trimethoprim-sulfamethoxazole in eradicating Escherichia coli from rectal cultures during or soon after therapy, but there were no differences at later follow-up visits. Adverse effects were equally common among the three treatment groups. We conclude that single-dose ofloxacin was less effective than 7 days of trimethoprim-sulfamethoxazole for treatment of uncomplicated cystitis in women, while the 3-day ofloxacin regimen and the trimethoprim-sulfamethoxazole regimen were not significantly different in efficacy.<\/jats:p>","DOI":"10.1128\/aac.35.7.1479","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"1479-1483","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":68,"title":["Single-dose and three-day regimens of ofloxacin versus trimethoprim-sulfamethoxazole for acute cystitis in women"],"prefix":"10.1128","volume":"35","author":[{"given":"T M","family":"Hooton","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Kuwamura","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P L","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W E","family":"Stamm","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.35.7.1479","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.35.7.1479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:18:49Z","timestamp":1645456729000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.35.7.1479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1128\/AAC.35.7.1479"],"URL":"https:\/\/doi.org\/10.1128\/aac.35.7.1479","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]},"assertion":[{"value":"1991-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}