{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:06:07Z","timestamp":1780077967332,"version":"3.54.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>The concentrations of doxycycline and 4-de-dimethylaminotetracycline required to inhibit 50% of collagenase activity were found to be 15 to 30 microM for human neutrophil and gingival crevicular fluid collagenases. Fibroblast collagenase was relatively resistant to inhibition by tetracyclines; the 50% inhibitory concentrations of doxycycline and 4-de-dimethylaminotetracycline were 280 and 510 microM, respectively.<\/jats:p>","DOI":"10.1128\/aac.36.1.227","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"227-229","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":89,"title":["Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential"],"prefix":"10.1128","volume":"36","author":[{"given":"K","family":"Suomalainen","sequence":"first","affiliation":[{"name":"Department of Periodontology, University of Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M","family":"Golub","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Ramamurthy","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V J","family":"Uitto","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Saari","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y T","family":"Konttinen","sequence":"additional","affiliation":[{"name":"Department of Periodontology, University of Helsinki, Finland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.1.227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.1.227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:27:01Z","timestamp":1645457221000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.36.1.227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1128\/AAC.36.1.227"],"URL":"https:\/\/doi.org\/10.1128\/aac.36.1.227","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]},"assertion":[{"value":"1992-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}