{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T06:51:35Z","timestamp":1648795895448},"reference-count":0,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[1992,11,1]],"date-time":"1992-11-01T00:00:00Z","timestamp":720576000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1992,11]]},"abstract":"<jats:p>The in vitro activity of RU 29246 was compared with those of other agents against 536 recent clinical isolates. The MICs of RU 29246 for 90% of members of the family Enterobacteriaceae tested (MIC90s) were less than 2 micrograms\/ml except those for Morganella spp. (16 micrograms\/ml) and Proteus spp. (8 micrograms\/ml). RU 29246 was active against Staphylococcus aureus (MIC90, &lt; or = 8 micrograms\/ml) and against Staphylococcus saprophyticus and coagulase-negative staphylococci (MIC90s, &lt; or = 2 micrograms\/ml). Streptococci and Neisseria gonorrhoeae were highly susceptible to RU 29246, and the activity of the agent against isolates of Streptococcus pneumoniae (MIC90, &lt; or = 0.5 micrograms\/ml), Haemophilus influenzae (MIC90, &lt; or = 2 micrograms\/ml), and Moraxella catarrhalis (MIC90, &lt; or = 2 micrograms\/ml) was comparable to those of the other cephalosporins tested. RU 29246 was insusceptible to hydrolysis by the common plasmid-mediated beta-lactamases (TEM-1 and SHV-1). However, hydrolysis by the new extended-spectrum beta-lactamases (TEM-3, TEM-5, and TEM-9) was detected. Results of the study suggested that RU 29246 should be investigated clinically for use in the treatment of a wide range of infections.<\/jats:p>","DOI":"10.1128\/aac.36.11.2360","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"2360-2364","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["In vitro activity of RU 29246, the active compound of the cephalosporin prodrug ester HR 916"],"prefix":"10.1128","volume":"36","author":[{"given":"G","family":"Riess","sequence":"first","affiliation":[{"name":"Department of Microbiology, Dudley Road Hospital, Birmingham, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Dudley Road Hospital, Birmingham, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Thornber","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Dudley Road Hospital, Birmingham, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Wise","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Dudley Road Hospital, Birmingham, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.11.2360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.11.2360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:26:23Z","timestamp":1645457183000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.36.11.2360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,11]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1992,11]]}},"alternative-id":["10.1128\/AAC.36.11.2360"],"URL":"https:\/\/doi.org\/10.1128\/aac.36.11.2360","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,11]]},"assertion":[{"value":"1992-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}