{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:14:43Z","timestamp":1789384483932,"version":"build-2803163510"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[1992,12,1]],"date-time":"1992-12-01T00:00:00Z","timestamp":723168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:p>The efficacy and safety of amphotericin B colloidal dispersion (ABCD) were compared with those of amphotericin B deoxycholate suspension (ABDS) (Fungizone) in a murine model of disseminated cryptococcosis. Mice were treated intravenously with either ABDS at 0.2, 0.8, or 3.2 mg\/kg of body weight per dose or ABCD at 0.8, 3.2, 6.4, 12.8, or 19.2 mg\/kg dose three times per week for 2 weeks. Excluding mice treated with ABDS at 3.2 mg\/kg, which was acutely lethal in 100% of mice, and ABCD at 19.2 mg\/kg, which also resulted in two early deaths, the survival of ABCD- and ABDS-treated groups was prolonged over survival of controls (P &lt; or = 0.05). Survival of ABCD (3.2 mg\/kg)-treated mice was improved over that of ABDS (0.2 mg\/kg)-treated mice (P &lt; 0.05); however, comparisons of mice given all other dosages of ABCD with mice given sublethal dosages of ABDS did not demonstrate differences in survival. Comparative fungal burdens in organs showed a decrease in liver (P &lt; 0.05) and spleen (P &lt; 0.05) burdens for ABCD with the 19.2-mg\/kg therapy versus those with ABDS with the 0.8-mg\/kg therapy and liver burdens for ABCD with the 12.8-mg\/kg therapy versus ABDS with the 0.8-mg\/kg therapy (P &lt; 0.05). There was no difference in organ burdens between therapy with ABCD at 0.8 mg\/kg and ABDS at 0.8 mg\/kg. These data show that the efficacy of ABCD is equal to that of ABDS on a milligram-per-kilogram basis for murine disseminated cryptococcosis. Because of its decreased toxicity, greater efficacy with ABCD could be achieved through doses fourfold higher than the 100% lethal dose for ABDS. Thus, ABCD shows promise as an effective but less toxic alternative to ABDS for the treatment of disseminated cryptococcosis.<\/jats:p>","DOI":"10.1128\/aac.36.12.2656","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"2656-2660","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["Efficacy and safety of amphotericin B colloidal dispersion compared with those of amphotericin B deoxycholate suspension for treatment of disseminated murine cryptococcosis"],"prefix":"10.1128","volume":"36","author":[{"given":"J S","family":"Hostetler","sequence":"first","affiliation":[{"name":"Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128-2699, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K V","family":"Clemons","sequence":"additional","affiliation":[{"name":"Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128-2699, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L H","family":"Hanson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128-2699, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128-2699, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.12.2656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.12.2656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:24:48Z","timestamp":1645457088000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.36.12.2656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1992,12]]}},"alternative-id":["10.1128\/AAC.36.12.2656"],"URL":"https:\/\/doi.org\/10.1128\/aac.36.12.2656","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,12]]},"assertion":[{"value":"1992-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}