{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:57:12Z","timestamp":1773709032652,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[1992,12,1]],"date-time":"1992-12-01T00:00:00Z","timestamp":723168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:p>In this study, the safety, tolerance, and pharmacokinetics of a single 1-g intravenous dose of cefepime (BMY-28142) were investigated. Twenty-three volunteers with various degrees of renal function were assigned to four trial groups according to glomerular filtration rates (GFR). Group IV consisted of five patients with end-stage renal disease undergoing treatment with hemodialysis. Cefepime concentrations in samples from plasma, urine, and infusion solutions were assayed with high-pressure liquid chromatography. The volume of distribution corresponded to the assumed extracellular fluid volume and did not differ significantly between the four groups. The area under the concentration-time curve increased as renal function decreased; in group II (GFR, 31 to 80 ml\/[min x 1.73 m2]; n = 6), it was already three times higher than in group I (GFR, &gt; or = 80 ml\/[min x 1.73 m2]; n = 5). Mean residence time was 2.4, 6.8, 11.4, and 31.6 h for the four groups, respectively. Total clearance decreased (97.2, 34.6, 19.8, and 6.3 ml\/[min x 1.73 m2]) with decreasing renal function, and a linear relationship between total plasma clearance and GFR was found with the regression equation y = 0.92x-2.0 (r = 0.991). Renal clearance was linearly correlated to GFR with the regression equation y = 0.87x-6.1 (r = 0.989), indicating that renal elimination is mainly by glomerular filtration. During hemodialysis, the extraction ratios were between 0.40 and 0.65. Dialysis clearance varied between 69.9 and 94.6 ml\/(min x 1.73 m2).<\/jats:p>","DOI":"10.1128\/aac.36.12.2676","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"2676-2680","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Pharmacokinetics of cefepime dihydrochloride arginine in subjects with renal impairment"],"prefix":"10.1128","volume":"36","author":[{"given":"J","family":"Cronqvist","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, University of Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Nilsson-Ehle","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Oqvist","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S R","family":"Norrby","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Lund, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.12.2676","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.12.2676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:24:08Z","timestamp":1645457048000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.36.12.2676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1992,12]]}},"alternative-id":["10.1128\/AAC.36.12.2676"],"URL":"https:\/\/doi.org\/10.1128\/aac.36.12.2676","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,12]]},"assertion":[{"value":"1992-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}