{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:03:28Z","timestamp":1648645408870},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1992,3,1]],"date-time":"1992-03-01T00:00:00Z","timestamp":699408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:p>E1040 showed the most potent activity (MIC for 90% of strains, 6.25 micrograms\/ml) among beta-lactams tested against 70 strains of imipenem-resistant Pseudomonas aeruginosa. Two strains showed high-level resistance to E1040; one strain produced a type II oxyiminocephalosporin-hydrolyzing beta-lactamase (group 3), and the other produced an enzyme similar to a type II penicillinase (OXA-1). Both beta-lactamases contributed to resistance to E1040.<\/jats:p>","DOI":"10.1128\/aac.36.3.684","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"684-686","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["In vitro activity of E1040 against imipenem-resistant Pseudomonas aeruginosa strains"],"prefix":"10.1128","volume":"36","author":[{"given":"M","family":"Watanabe","sequence":"first","affiliation":[{"name":"Episome Institute, Seta-gun, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Inoue","sequence":"additional","affiliation":[{"name":"Episome Institute, Seta-gun, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Katsu","sequence":"additional","affiliation":[{"name":"Episome Institute, Seta-gun, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Iyobe","sequence":"additional","affiliation":[{"name":"Episome Institute, Seta-gun, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Mitsuhashi","sequence":"additional","affiliation":[{"name":"Episome Institute, Seta-gun, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.3.684","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.3.684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:19:47Z","timestamp":1645456787000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.36.3.684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["10.1128\/AAC.36.3.684"],"URL":"https:\/\/doi.org\/10.1128\/aac.36.3.684","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,3]]},"assertion":[{"value":"1992-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}