{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:00:21Z","timestamp":1762866021997},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1992,4,1]],"date-time":"1992-04-01T00:00:00Z","timestamp":702086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:p>The MICs of four new quinolones, sparfloxacin (AT-4140, CI-978), PD 131628 (the active form of the prodrug CI-990), temafloxacin, and Win 57273, compared with those of ciprofloxacin and ofloxacin were tested against 53 penicillin-susceptible, 35 penicillin intermediate-resistant, and 51 penicillin-resistant pneumococci. Susceptibility to RP 59500, a new streptogramin, was also tested and compared with those to the quinolones, erythromycin, and vancomycin. All MICs were determined by a standardized agar dilution method by using Mueller-Hinton agar supplemented with sheep blood. Quinolone, vancomycin, and RP 59500 susceptibilities were not affected by susceptibility or resistance to penicillin. For Win 57273, the MICs for 50% (MIC50) and 90% (MIC90) of strains tested were 0.015 and 0.03 micrograms\/ml, respectively. MIC50S of both sparfloxacin and PD 131628 were 0.25 micrograms\/ml, and MIC90S were 0.5 micrograms\/ml. The MIC50 of temafloxacin was 0.5 micrograms\/ml, and the MIC90 was 1.0 micrograms\/ml. By comparison, ofloxacin and ciprofloxacin both yielded MIC50S of 1.0 micrograms\/ml and MIC90s of 2.0 micrograms\/ml. RP 59500 yielded an MIC50 of 0.5 microgram\/ml and an MIC90 of 1.0 microgram\/ml and was only 1 doubling dilution less active against 17 erythromycin-resistant strains. Vancomycin was active against all strains (MIC50, 0.25 microgram\/ml; MIC90, 0.5 microgram\/ml). All four experimental quinolones as well as RP 59500 show promise for therapy of infections with penicillin-resistant and -susceptible pneumococci.<\/jats:p>","DOI":"10.1128\/aac.36.4.856","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"856-859","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":62,"title":["Susceptibilities of penicillin-susceptible and -resistant strains of Streptococcus pneumoniae to RP 59500, vancomycin, erythromycin, PD 131628, sparfloxacin, temafloxacin, win 57273, ofloxacin, and ciprofloxacin"],"prefix":"10.1128","volume":"36","author":[{"given":"S K","family":"Spangler","sequence":"first","affiliation":[{"name":"Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P C","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.4.856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.4.856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:25:18Z","timestamp":1645457118000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.36.4.856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,4]]}},"alternative-id":["10.1128\/AAC.36.4.856"],"URL":"https:\/\/doi.org\/10.1128\/aac.36.4.856","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4]]},"assertion":[{"value":"1992-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}