{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T11:47:30Z","timestamp":1716983250701},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1992,4,1]],"date-time":"1992-04-01T00:00:00Z","timestamp":702086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:p>The in vitro activity of Ro 23-9424 against bacterial isolates from patients with cancer was compared with those of fleroxacin, ciprofloxacin, cefoperazone, and ceftazidime. Ro 23-9424 inhibited the majority of the members of the family Enterobacteriaceae and all Aeromonas isolates at a concentration of less than or equal to 1.0 micrograms\/ml. It was also active against Acinetobacter spp. and Haemophilus influenzae, including beta-lactamase-producing strains. The MIC for 90% of isolates (MIC90) of Pseudomonas aeruginosa was 16.0 micrograms\/ml. All group A and B streptococci were inhibited by less than or equal to 0.25 micrograms\/ml, and 90% of group G streptococci and Streptococcus pneumoniae were inhibited by 1.0 micrograms\/ml. All methicillin-susceptible strains of Staphylococcus aureus and 60% of methicillin-resistant strains were susceptible to 2.0 micrograms of Ro 23-9424 per ml, whereas the MIC90 for Staphylococcus epidermidis and Staphylococcus hominis isolates was 4.0 micrograms\/ml. Staphylococcus haemolyticus and Enterococcus spp. were less susceptible; MIC90s for them were 16.0 and 32.0 micrograms\/ml. Ro 23-9424 has a broad antibacterial spectrum and potential utility for therapy of infections in cancer patients.<\/jats:p>","DOI":"10.1128\/aac.36.4.879","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"879-882","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["In vitro activity of Ro 23-9424, a dual-action antibacterial agent, against bacterial isolates from cancer patients compared with those of other agents"],"prefix":"10.1128","volume":"36","author":[{"given":"K V","family":"Rolston","sequence":"first","affiliation":[{"name":"Department of Medical Specialties, University of Texas M. D. Anderson Cancer Center, Houston 77030."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H T","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties, University of Texas M. D. Anderson Cancer Center, Houston 77030."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D H","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties, University of Texas M. D. Anderson Cancer Center, Houston 77030."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties, University of Texas M. D. Anderson Cancer Center, Houston 77030."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G P","family":"Bodey","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties, University of Texas M. D. Anderson Cancer Center, Houston 77030."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.4.879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.4.879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:24:56Z","timestamp":1645457096000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.36.4.879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,4]]}},"alternative-id":["10.1128\/AAC.36.4.879"],"URL":"https:\/\/doi.org\/10.1128\/aac.36.4.879","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,4]]},"assertion":[{"value":"1992-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}