{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T02:03:29Z","timestamp":1692410609988},"reference-count":0,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[1992,8,1]],"date-time":"1992-08-01T00:00:00Z","timestamp":712627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1992,8]]},"abstract":"<jats:p>The in vitro activity of MC-352, 3,4'-dideoxy-5-O-mycaminosyltylonolide, was compared with those of erythromycin, clarithromycin, and rokitamycin. The MC-352 MIC90 (MIC for 90% of isolates) for erythromycin-susceptible Staphylococcus aureus and Staphylococcus epidermidis was less than or equal to 1 microgram\/ml, similar to those of the other agents. The MC-352 MIC50 for erythromycin-resistant S. aureus was 2 micrograms\/ml, similar to that of rokitamycin. The MC-352 MIC90 (0.12 micrograms\/ml) for Streptococcus pyogenes was similar to those of erythromycin and clarithromycin and superior to that of rokitamycin, and the MC-352 MIC90 for group B, C, and G streptococci was 0.25 microgram\/ml. MC-352 and clarithromycin had an MIC90 of 0.12 microgram\/ml for Streptococcus pneumoniae. Erythromycin-susceptible Enterococcus faecalis was inhibited by MC-352 at 1 microgram\/ml, but the MIC for constitutively erythromycin-resistant isolates was greater than 16 micrograms\/ml. Legionella pneumophila was inhibited by less than or equal to 0.25 microgram\/ml. MC-352 was the most active agent against Bacteroides fragilis, with an MIC90 of 8 micrograms\/ml, and was more active than the other agents against Haemophilus influenzae, with an MIC90 of 4 micrograms\/ml. Moraxella spp. were inhibited by MC-352 at less than or equal to 0.25 microgram\/ml. The MIC90 for Escherichia coli, Klebsiella pneumoniae, and Salmonella, Shigella, Yersinia, Enterobacter, Citrobacter, and Serratia spp. was greater than or equal to 32 micrograms\/ml. MC-352 was bactericidal for S. pyogenes and S. pneumoniae, and its activity was not altered by human serum.<\/jats:p>","DOI":"10.1128\/aac.36.8.1699","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"1699-1702","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["In vitro activity of MC-352, a new 16-membered macrolide"],"prefix":"10.1128","volume":"36","author":[{"given":"N X","family":"Chin","sequence":"first","affiliation":[{"name":"Department of Medicine, College of Physicians &amp; Surgeons, Columbia University, New York, New York 10032."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H C","family":"Neu","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Physicians &amp; Surgeons, Columbia University, New York, New York 10032."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.8.1699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.36.8.1699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:29:02Z","timestamp":1645457342000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.36.8.1699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1992,8]]}},"alternative-id":["10.1128\/AAC.36.8.1699"],"URL":"https:\/\/doi.org\/10.1128\/aac.36.8.1699","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,8]]},"assertion":[{"value":"1992-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}