{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T21:22:36Z","timestamp":1700515356917},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1993,2,1]],"date-time":"1993-02-01T00:00:00Z","timestamp":728524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1993,2]]},"abstract":"<jats:p>The effect of treatment with interleukin-8 (IL-8), a neutrophil-activating cytokine, was investigated in normal and neutropenic mice infected with a lethal dose of Pseudomonas aeruginosa, Klebsiella pneumoniae, or Plasmodium berghei. Intraperitoneal (i.p.) IL-8 treatment was associated with accelerated death when IL-8 was administered shortly before i.p. infection with P. aeruginosa or shortly after i.p. infection with P. aeruginosa and K. pneumoniae. Histopathological analyses demonstrated a tendency to more severe organ lesions in IL-8-treated mice. Only nonneutropenic mice that received IL-8 shortly before the infectious challenge and at the site of infection were protected by IL-8. Whether IL-8 is protective of or detrimental to the survival of infection appeared to depend on the presence of bacteria at the injection site and on the presence of neutropenia. IL-8 may be an important participant in the cascade of interacting cytokines that is induced by the lethal infectious challenge.<\/jats:p>","DOI":"10.1128\/aac.37.2.276","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"276-280","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["Effects of interleukin-8 on nonspecific resistance to infection in neutropenic and normal mice"],"prefix":"10.1128","volume":"37","author":[{"given":"M T","family":"Vogels","sequence":"first","affiliation":[{"name":"Department of Medicine, University Hospital, Nijmegen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I J","family":"Lindley","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital, Nijmegen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Curfs","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital, Nijmegen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W M","family":"Eling","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital, Nijmegen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J W","family":"van der Meer","sequence":"additional","affiliation":[{"name":"Department of Medicine, University Hospital, Nijmegen, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.2.276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.2.276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:32:54Z","timestamp":1645457574000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.37.2.276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,2]]}},"alternative-id":["10.1128\/AAC.37.2.276"],"URL":"https:\/\/doi.org\/10.1128\/aac.37.2.276","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,2]]},"assertion":[{"value":"1993-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}