{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:29:05Z","timestamp":1761488945245},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1993,3,1]],"date-time":"1993-03-01T00:00:00Z","timestamp":730944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1993,3]]},"abstract":"<jats:p>Azithromycin, rifabutin, and rifapentine were used to treat or prevent disseminated Mycobacterium avium complex (MAC) infections produced in rats immunosuppressed with cyclosporine. Animals with bacteremic infections were treated 1 week after intravenous inoculation with 10(7) CFU of MAC with azithromycin, 100 mg\/kg of body weight administered subcutaneously for 5 days and then 75 mg\/kg on Monday, Wednesday, and Friday, or with rifabutin or rifapentine, 20 mg\/kg administered intraperitoneally on Monday through Friday. All three drugs showed efficacy after 1 and 2 months. Rifabutin cleared the organisms from tissues more rapidly than azithromycin or rifapentine. To approximate prophylaxis, treatment was started 2 weeks before intravenous inoculation with 10(4) organisms. MAC infections were undetectable in treated animals after 4 months, while control animals had disseminated infections. These findings support the rationale for clinical trials of treatment and prophylaxis with these agents. The cyclosporine-treated rat appears to be a useful model in which to evaluate compounds for the treatment and prophylaxis of disseminated MAC infections.<\/jats:p>","DOI":"10.1128\/aac.37.3.398","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"398-402","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Azithromycin, rifabutin, and rifapentine for treatment and prophylaxis of Mycobacterium avium complex in rats treated with cyclosporine"],"prefix":"10.1128","volume":"37","author":[{"given":"S T","family":"Brown","sequence":"first","affiliation":[{"name":"Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F F","family":"Edwards","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E M","family":"Bernard","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Tong","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.3.398","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.3.398","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:31:59Z","timestamp":1645457519000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.37.3.398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,3]]}},"alternative-id":["10.1128\/AAC.37.3.398"],"URL":"https:\/\/doi.org\/10.1128\/aac.37.3.398","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3]]},"assertion":[{"value":"1993-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}