{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T19:51:08Z","timestamp":1781034668784,"version":"3.54.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1993,5,1]],"date-time":"1993-05-01T00:00:00Z","timestamp":736214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:p>Over a period of 208 days a quinapyramine-resistant population was derived in vivo from a quinapyramine-susceptible clone of Trypanosoma congolense: IL 1180. While the dose of quinapyramine sulfate required to cure 50% of mice infected with the parental clone was 0.23 mg\/kg of body weight, the 50% curative dose for the resistant derivative, IL 1180\/Stabilate 12, was greater than 9.6 mg\/kg. This approximately 40-fold increase in resistance to quinapyramine was shown to be associated with an 8-fold increase in resistance to isometamidium, a 28-fold increase in resistance to homidium, and a 5.5-fold increase in resistance to diminazene. Cross-resistance to homidium and diminazene was also demonstrated in goats. Two clones derived from the drug-resistant derivative underwent cyclical development in Glossina morsitans centralis, producing mature infection rates of 39.6 and 23.9%. Thus, induction of resistance to quinapyramine in T. congolense IL 1180 was associated with cross-resistance to isometamidium, homidium, and diminazene and did not compromise the population's ability to undergo full cyclical development in tsetse flies.<\/jats:p>","DOI":"10.1128\/aac.37.5.1163","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"1163-1166","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Derivation and characterization of a quinapyramine-resistant clone of Trypanosoma congolense"],"prefix":"10.1128","volume":"37","author":[{"given":"G","family":"Ndoutamia","sequence":"first","affiliation":[{"name":"International Laboratory for Research on Animal Diseases, Nairobi, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S K","family":"Moloo","sequence":"additional","affiliation":[{"name":"International Laboratory for Research on Animal Diseases, Nairobi, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N B","family":"Murphy","sequence":"additional","affiliation":[{"name":"International Laboratory for Research on Animal Diseases, Nairobi, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A S","family":"Peregrine","sequence":"additional","affiliation":[{"name":"International Laboratory for Research on Animal Diseases, Nairobi, Kenya."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.5.1163","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.5.1163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:34:20Z","timestamp":1645457660000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.37.5.1163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,5]]}},"alternative-id":["10.1128\/AAC.37.5.1163"],"URL":"https:\/\/doi.org\/10.1128\/aac.37.5.1163","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,5]]},"assertion":[{"value":"1993-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}