{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T11:44:27Z","timestamp":1748259867637},"reference-count":0,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1993,5,1]],"date-time":"1993-05-01T00:00:00Z","timestamp":736214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:p>The novel triazole D0870 was tested for in vitro activity, as well as in vivo in a murine model of pulmonary blastomycosis. In vitro, D0870 had inhibitory and fungicidal activity against Blastomyces dermatitidis (MIC = 0.048 microgram\/ml; minimal fungicidal concentration = 0.097 microgram\/ml). In vivo, D0870 was approximately 100-fold more active than fluconazole on the basis of milligrams per kilogram of body weight given once daily (QD) against blastomycosis. D0870 doses of both 1 or 10 mg\/kg given QD and 10 or 100 mg\/kg given every other day prolonged survival (P &lt; 0.001) over fluconazole (100 mg\/kg given QD). A D0870 dosage of 1 mg\/kg QD was equivalent to fluconazole given at 100 mg\/kg in reduction of lung burdens of B. dermatitidis, and D0870 administered at 10 mg\/kg QD and 10 or 100 mg\/kg every other day caused greater reduction (P &lt; 0.001). However, D0870 at 100 mg\/kg given QD was lethally toxic, whereas fluconazole at 100 mg\/kg was not. These results indicate that D0870 is an effective therapy for murine blastomycosis and should be further tested.<\/jats:p>","DOI":"10.1128\/aac.37.5.1177","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"1177-1179","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Activities of the triazole D0870 in vitro and against murine blastomycosis"],"prefix":"10.1128","volume":"37","author":[{"given":"K V","family":"Clemons","sequence":"first","affiliation":[{"name":"Department of Medicine, Santa Clara Valley Medical Center, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L H","family":"Hanson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Santa Clara Valley Medical Center, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Medicine, Santa Clara Valley Medical Center, California."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.5.1177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.5.1177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:33:36Z","timestamp":1645457616000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.37.5.1177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,5]]}},"alternative-id":["10.1128\/AAC.37.5.1177"],"URL":"https:\/\/doi.org\/10.1128\/aac.37.5.1177","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,5]]},"assertion":[{"value":"1993-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}