{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:38:58Z","timestamp":1772210338600,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[1993,7,1]],"date-time":"1993-07-01T00:00:00Z","timestamp":741484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:p>In experimental visceral leishmaniasis, euthymic but not athymic (nude) BALB\/c mice respond to conventional treatment with pentavalent antimony, indicating that the in vivo efficacy of antimony is T cell dependent. This finding correlates with frequent antimony treatment failures for T-cell-deficient patients with visceral leishmaniasis. To determine whether the in vivo efficacies of alternative antileishmanial agents also require T cells, Leishmania donovani-infected euthymic and nude BALB\/c mice were treated with pentamidine or amphotericin B. Pentamidine induced leishmanistatic activity in euthymic mice but had little effect in nude mice. In contrast, amphotericin B exerted potent leishmanicidal activities in both euthymic and nude animals. These results suggest that amphotericin B may be of particular use for T-cell-deficient patients with visceral leishmaniasis.<\/jats:p>","DOI":"10.1128\/aac.37.7.1504","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"1504-1505","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":34,"title":["Treatment of experimental visceral leishmaniasis in a T-cell-deficient host: response to amphotericin B and pentamidine"],"prefix":"10.1128","volume":"37","author":[{"given":"H W","family":"Murray","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hariprashad","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R E","family":"Fichtl","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Cornell University Medical College, New York, New York 10021."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.7.1504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.7.1504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:32:33Z","timestamp":1645457553000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.37.7.1504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1128\/AAC.37.7.1504"],"URL":"https:\/\/doi.org\/10.1128\/aac.37.7.1504","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]},"assertion":[{"value":"1993-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}