{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:10:10Z","timestamp":1761844210485},"reference-count":0,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[1993,9,1]],"date-time":"1993-09-01T00:00:00Z","timestamp":746841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:p>TLC G-65, a liposome-encapsulated gentamicin, was given intravenously twice weekly for 4 weeks to AIDS patients with Mycobacterium avium-M. intracellulare complex (MAC) bacteremia at 1.7 mg of gentamicin per kg of body weight per infusion (4 patients), 3.4 mg\/kg (10 patients), and 5.1 mg\/kg (7 patients). MAC colony counts in blood fell by 75% or more in all three groups (P &lt; 0.005). Drug resistance did not emerge during the study period. Transient renal insufficiency developed in one patient; no other adverse effects were detected. Liposome-encapsulated gentamicin is a potential therapy for MAC infections in AIDS patients.<\/jats:p>","DOI":"10.1128\/aac.37.9.1869","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"1869-1872","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["Liposome-encapsulated gentamicin treatment of Mycobacterium avium-Mycobacterium intracellulare complex bacteremia in AIDS patients"],"prefix":"10.1128","volume":"37","author":[{"given":"S D","family":"Nightingale","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, University of Texas Southwestern Medical School, Dallas 75235-9103."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S L","family":"Saletan","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, University of Texas Southwestern Medical School, Dallas 75235-9103."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C E","family":"Swenson","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, University of Texas Southwestern Medical School, Dallas 75235-9103."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, University of Texas Southwestern Medical School, Dallas 75235-9103."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Watson","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, University of Texas Southwestern Medical School, Dallas 75235-9103."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F G","family":"Pilkiewicz","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, University of Texas Southwestern Medical School, Dallas 75235-9103."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E G","family":"Silverman","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, University of Texas Southwestern Medical School, Dallas 75235-9103."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S X","family":"Cal","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, University of Texas Southwestern Medical School, Dallas 75235-9103."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.9.1869","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.9.1869","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:36:57Z","timestamp":1645457817000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.37.9.1869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1128\/AAC.37.9.1869"],"URL":"https:\/\/doi.org\/10.1128\/aac.37.9.1869","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]},"assertion":[{"value":"1993-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}