{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:22:54Z","timestamp":1787163774653,"version":"build-2736575974"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[1993,9,1]],"date-time":"1993-09-01T00:00:00Z","timestamp":746841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:p>After an outbreak of three cases of serogroup B meningococcal disease at a Norwegian college, 84 of 392 (21%) subjects were tonsillopharyngeal carriers of Neisseria meningitidis. To eradicate meningococcal carriage, 80 volunteers received a single dose of 400 mg of ofloxacin. Three days after treatment, all 75 evaluable volunteers were culture negative for N. meningitidis, and after 7 days none carried the strain that they carried initially, as judged by DNA fingerprinting. A single dose of ofloxacin was found to be 97.2% effective in eradicating carriage of N. meningitidis for a period of 33 days. The carriage acquisition rate among treated students was four times higher than that among nontreated noncarriers (P = 0.02). After ofloxacin treatment, no case of meningococcal disease occurred for 6 months. Ofloxacin may thus prevent the outbreak and spread of meningococcal disease.<\/jats:p>","DOI":"10.1128\/aac.37.9.2024","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T20:05:50Z","timestamp":1340827550000},"page":"2024-2026","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Use of single-dose ofloxacin to eradicate tonsillopharyngeal carriage of Neisseria meningitidis"],"prefix":"10.1128","volume":"37","author":[{"given":"O H","family":"Gilja","sequence":"first","affiliation":[{"name":"Medical Department B, University of Bergen, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Halstensen","sequence":"additional","affiliation":[{"name":"Medical Department B, University of Bergen, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Digranes","sequence":"additional","affiliation":[{"name":"Medical Department B, University of Bergen, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Mylvaganam","sequence":"additional","affiliation":[{"name":"Medical Department B, University of Bergen, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Aksnes","sequence":"additional","affiliation":[{"name":"Medical Department B, University of Bergen, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E A","family":"H\u00f8iby","sequence":"additional","affiliation":[{"name":"Medical Department B, University of Bergen, Norway."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.9.2024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.37.9.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T10:36:41Z","timestamp":1645439801000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.37.9.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1128\/AAC.37.9.2024"],"URL":"https:\/\/doi.org\/10.1128\/aac.37.9.2024","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]},"assertion":[{"value":"1993-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}