{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T17:43:10Z","timestamp":1772818990897,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1994,3,1]],"date-time":"1994-03-01T00:00:00Z","timestamp":762480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1994,3]]},"abstract":"<jats:p>The glycylcyclines designated CL 329,998 and CL 331,002 are N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, respectively. In vitro activities of these two antimicrobial agents were compared with those of tetracycline, minocycline, and seven other antimicrobial agents against 412 gram-positive organisms. Both new drugs were significantly more active than minocycline against methicillin-resistant Staphylococcus aureus (MICs for 90% of isolates tested, 0.25 and 0.5 microgram\/ml versus 4 micrograms\/ml). CL 329,998 inhibited all streptococci, lactobacilli, and Leuconostoc spp. at concentrations of &lt; or = 0.5 microgram\/ml, with CL 331,002 slightly less active against some species. All enterococci, including minocycline-resistant and multidrug-resistant isolates, were inhibited at &lt; or = 0.5- and &lt; or = 1.0-microgram\/ml concentrations of the new drugs, respectively. Only bacteriostatic activity was evident by time-kill curves. The two glycylcyclines demonstrated activities in vitro that were superior to those of minocycline against several gram-positive bacterial species, and at relatively low concentrations, they inhibited isolates resistant to both tetracycline and minocycline.<\/jats:p>","DOI":"10.1128\/aac.38.3.534","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"534-541","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["In vitro activities of two glycylcyclines against gram-positive bacteria"],"prefix":"10.1128","volume":"38","author":[{"given":"G M","family":"Eliopoulos","sequence":"first","affiliation":[{"name":"Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C B","family":"Wennersten","sequence":"additional","affiliation":[{"name":"Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C","family":"Moellering","sequence":"additional","affiliation":[{"name":"Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.38.3.534","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.38.3.534","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:36:41Z","timestamp":1645457801000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.38.3.534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,3]]}},"alternative-id":["10.1128\/AAC.38.3.534"],"URL":"https:\/\/doi.org\/10.1128\/aac.38.3.534","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3]]},"assertion":[{"value":"1994-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}