{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T14:58:36Z","timestamp":1693407516887},"reference-count":0,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[1994,7,1]],"date-time":"1994-07-01T00:00:00Z","timestamp":773020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1994,7]]},"abstract":"<jats:p>Bay Y 3118 is a new quinolone derivative with pronounced activity against gram-positive bacteria including the facultatively intracellular bacterium Listeria monocytogenes. Bay Y 3118 was tested in vitro and in animal models of listeriosis. All strains of L. monocytogenes and other Listeria spp. were highly susceptible in vitro; the MICs for these organisms ranged from 0.062 to 0.25 micrograms\/ml. Bay Y 3118 was rapidly bactericidal in vitro, with a postantibiotic effect occurring for 3 h after removal of the antibiotic. L. monocytogenes was eliminated from infected L929 cells treated with Bay Y 3118, suggesting a bactericidal effect on the listeriae in these cells. Immunocompetent mice were rapidly cured by treatment with 4 mg every 12 h. Concomitantly, the levels of interleukin 6 and gamma interferon in mouse sera declined rapidly. In immunocompetent mice, treatment with 2 mg of Bay Y 3118 every 12 h resulted in a greater initial reduction in the listerial counts in the organs than treatment with 2 mg of ampicillin every 12 h. Bay Y 3118 completely eliminated L. monocytogenes from the livers and spleens of chronically infected nude mice. However, some of the bacteria reappeared after the cessation of therapy. In conclusion, Bay Y 3118 is an excellent candidate substance for the therapy of infections caused by facultatively intracellular gram-positive bacteria such as L. monocytogenes.<\/jats:p>","DOI":"10.1128\/aac.38.7.1501","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"1501-1506","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Bay Y 3118, a new quinolone derivative, rapidly eradicates Listeria monocytogenes from infected mice and L929 cells"],"prefix":"10.1128","volume":"38","author":[{"given":"T","family":"Nichterlein","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kretschmar","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Budeanu","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Bauer","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Linss","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Hof","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.38.7.1501","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.38.7.1501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:35:53Z","timestamp":1645457753000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.38.7.1501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1994,7]]}},"alternative-id":["10.1128\/AAC.38.7.1501"],"URL":"https:\/\/doi.org\/10.1128\/aac.38.7.1501","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7]]},"assertion":[{"value":"1994-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}