{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:09:14Z","timestamp":1761059354222},"reference-count":0,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[1994,9,1]],"date-time":"1994-09-01T00:00:00Z","timestamp":778377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1994,9]]},"abstract":"<jats:p>(-)-beta-L-2',3'-Dideoxycytidine (beta-L-DDC), (+)-beta-D-2',3'-dideoxycytidine (beta-D-DDC), (-)-beta-L-2',3'-dideoxy-5-fluorocytidine (beta-L-FDDC), (-)-beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine (beta-L-FTC), and (+)-beta-D-1,3-dioxolane-5-fluorocytidine (beta-D-FDOC) were evaluated for their anti-hepatitis B virus (anti-HBV) activities in HBV-transfected human liver cells (2.2.15). The order of decreasing potency for the compounds at the 90% effect level was beta-D-FDOC &gt; beta-L-FTC &gt; beta-L-FDDC approximately beta-L-DDC &gt;&gt; beta-D-DDC. Inhibition of HBV in transfected liver cells by the cytosine nucleosides was selective. The beta-L-nucleoside-5'-triphosphates were consistently more potent inhibitors of woodchuck hepatitis virus DNA polymerase than the corresponding natural beta-D-enantiomers.<\/jats:p>","DOI":"10.1128\/aac.38.9.2172","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:05:50Z","timestamp":1340841950000},"page":"2172-2174","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":93,"title":["Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro"],"prefix":"10.1128","volume":"38","author":[{"given":"R F","family":"Schinazi","sequence":"first","affiliation":[{"name":"Georgia VA Research Center for AIDS and HIV Infections, Veterans Affairs Medical Center, Decatur 30033."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Gosselin","sequence":"additional","affiliation":[{"name":"Georgia VA Research Center for AIDS and HIV Infections, Veterans Affairs Medical Center, Decatur 30033."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Faraj","sequence":"additional","affiliation":[{"name":"Georgia VA Research Center for AIDS and HIV Infections, Veterans Affairs Medical Center, Decatur 30033."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B E","family":"Korba","sequence":"additional","affiliation":[{"name":"Georgia VA Research Center for AIDS and HIV Infections, Veterans Affairs Medical Center, Decatur 30033."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D C","family":"Liotta","sequence":"additional","affiliation":[{"name":"Georgia VA Research Center for AIDS and HIV Infections, Veterans Affairs Medical Center, Decatur 30033."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C K","family":"Chu","sequence":"additional","affiliation":[{"name":"Georgia VA Research Center for AIDS and HIV Infections, Veterans Affairs Medical Center, Decatur 30033."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Math\u00e9","sequence":"additional","affiliation":[{"name":"Georgia VA Research Center for AIDS and HIV Infections, Veterans Affairs Medical Center, Decatur 30033."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Imbach","sequence":"additional","affiliation":[{"name":"Georgia VA Research Center for AIDS and HIV Infections, Veterans Affairs Medical Center, Decatur 30033."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J P","family":"Sommadossi","sequence":"additional","affiliation":[{"name":"Georgia VA Research Center for AIDS and HIV Infections, Veterans Affairs Medical Center, Decatur 30033."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.38.9.2172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.38.9.2172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:40:07Z","timestamp":1645458007000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.38.9.2172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1994,9]]}},"alternative-id":["10.1128\/AAC.38.9.2172"],"URL":"https:\/\/doi.org\/10.1128\/aac.38.9.2172","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,9]]},"assertion":[{"value":"1994-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}