{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:22:28Z","timestamp":1789593748271,"version":"build-2803163510"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>In this study, concentrations of amikacin in blood and bronchial secretions of 10 patients with mechanical ventilation for acute respiratory failure due to pneumonia were measured. One-half of the patients received amikacin twice daily, and the others received once-daily administration. Concentrations in bronchial secretions of the patients treated twice daily ranged from 3 to 4 mg\/liter, i.e., they were similar to those in previously published reports. Peak concentrations in bronchial secretions occurred between 3 and 4 h after the onset of infusion, and they reached 4.8 +\/- 2.6 mg\/liter on day 1 and 4.0 +\/- 2.7 mg\/liter on day 3. For the patients treated with amikacin once daily, concentrations in bronchial secretions were more than twofold higher, above 8 mg\/liter for 12 h. Peak concentrations in bronchial secretions occurred between 3 and 4 h after the onset of infusion and reached 13.6 +\/- 9.3 mg\/liter on day 1 and 10.4 +\/- 3.5 mg\/liter on day 3. These concentrations are higher than the MICs for less sensitive bacterial strains, such as Acinetobacter spp. and Pseudomonas aeruginosa.<\/jats:p>","DOI":"10.1128\/aac.39.1.264","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:06:25Z","timestamp":1340841985000},"page":"264-267","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Amikacin levels in bronchial secretions of 10 pneumonia patients with respiratory support treated once daily versus twice daily"],"prefix":"10.1128","volume":"39","author":[{"given":"C","family":"Santr\u00e9","sequence":"first","affiliation":[{"name":"Intensive Care and Infectious Diseases Unit, Lille University Medicine School, Tourcoing, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Georges","sequence":"additional","affiliation":[{"name":"Intensive Care and Infectious Diseases Unit, Lille University Medicine School, Tourcoing, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Jacquier","sequence":"additional","affiliation":[{"name":"Intensive Care and Infectious Diseases Unit, Lille University Medicine School, Tourcoing, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Leroy","sequence":"additional","affiliation":[{"name":"Intensive Care and Infectious Diseases Unit, Lille University Medicine School, Tourcoing, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Beuscart","sequence":"additional","affiliation":[{"name":"Intensive Care and Infectious Diseases Unit, Lille University Medicine School, Tourcoing, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Buguin","sequence":"additional","affiliation":[{"name":"Intensive Care and Infectious Diseases Unit, Lille University Medicine School, Tourcoing, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Beaucaire","sequence":"additional","affiliation":[{"name":"Intensive Care and Infectious Diseases Unit, Lille University Medicine School, Tourcoing, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.39.1.264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.39.1.264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:01:28Z","timestamp":1645473688000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.39.1.264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1128\/AAC.39.1.264"],"URL":"https:\/\/doi.org\/10.1128\/aac.39.1.264","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]},"assertion":[{"value":"1995-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}