{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:27:32Z","timestamp":1758126452153},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:p>Benanomicin A (BNM-A) has antimycotic activities via binding to mannan in the cell walls of fungi. Anti-Pneumocystis carinii activity of the agent was examined in the P. carinii-infected BALB\/c nu\/nu female mouse model because P. carinii also possesses mannan in the membranes. The infected mice were treated with intraperitoneal injections of six doses of BNM-A (1, 2.5, 5, 10, 30, and 100 mg\/kg of body weight), 4 mg of pentamidine isethionate per kg, 100 mg of sulfamethoxazole per kg combined with 20 mg of trimethoprim per kg (co-trimoxazole), or saline for 21 days. Each dosage group consisted of 10 mice. During treatment, five mice in the control group (saline) died, whereas 8 to 10 mice in all treatment groups survived. Almost the same efficacies were obtained for the groups treated with 5 mg or more and 10 mg or more of BNM-A per kg regarding the weight and number, respectively, of cysts found in the lungs as were obtained for the groups treated with pentamidine isethionate and co-trimoxazole. Overall, a dose of 10 mg of BNM-A per kg was effective against P. carinii pneumonia infection in the mice. Thus, BNM-A is a good candidate for a novel treatment for P. carinii pneumonia as a compound with a new mechanism of action against P. carinii.<\/jats:p>","DOI":"10.1128\/aac.39.3.720","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:06:25Z","timestamp":1340841985000},"page":"720-724","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Successful treatment of Pneumocystis carinii Pneumonia in mice with benanomicin A (ME1451)"],"prefix":"10.1128","volume":"39","author":[{"given":"A","family":"Yasuoka","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Komuro","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kitada","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Shibahara","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Tokyo, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.39.3.720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.39.3.720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:03:20Z","timestamp":1645473800000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.39.3.720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["10.1128\/AAC.39.3.720"],"URL":"https:\/\/doi.org\/10.1128\/aac.39.3.720","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]},"assertion":[{"value":"1995-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}