{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:27:27Z","timestamp":1789954047827,"version":"4.0.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[1995,6,1]],"date-time":"1995-06-01T00:00:00Z","timestamp":801964800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p>Klebsiella oxytoca mutants resistant to a variety of beta-lactams were obtained in vitro on aztreonam. Constitutive beta-lactamase production was much higher in the mutants than in the susceptible strains (75-fold). The only difference observed in these mutants compared with the susceptible strains were point mutations in the Pribnow box: a transversion (G--&gt;T) in the first base for one mutant or a transition (G--&gt;A) in the fifth base of the -10 consensus sequence for the other three mutants. The transcriptional output of the beta-lactamase gene (blaOXY) from the mutants was significantly higher than that of the blaOXY gene from the susceptible strains.<\/jats:p>","DOI":"10.1128\/aac.39.6.1365","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:06:25Z","timestamp":1340841985000},"page":"1365-1368","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":43,"title":["Point mutation in the pribnow box, the molecular basis of beta-lactamase overproduction in Klebsiella oxytoca"],"prefix":"10.1128","volume":"39","author":[{"given":"B","family":"Fournier","sequence":"first","affiliation":[{"name":"Laboratoire de Microbiologie, H\u00f4pital Saint-Louis, Universit\u00e9 Paris VII, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C Y","family":"Lu","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, H\u00f4pital Saint-Louis, Universit\u00e9 Paris VII, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P H","family":"Lagrange","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, H\u00f4pital Saint-Louis, Universit\u00e9 Paris VII, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, H\u00f4pital Saint-Louis, Universit\u00e9 Paris VII, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Philippon","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie, H\u00f4pital Saint-Louis, Universit\u00e9 Paris VII, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.39.6.1365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.39.6.1365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:59:17Z","timestamp":1645473557000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.39.6.1365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,6]]}},"alternative-id":["10.1128\/AAC.39.6.1365"],"URL":"https:\/\/doi.org\/10.1128\/aac.39.6.1365","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6]]},"assertion":[{"value":"1995-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}