{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:36:55Z","timestamp":1762623415237},"reference-count":0,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:p>Using a rabbit model of meningitis, we sought to determine whether concomitant use of dexamethasone affects the penetration and efficacy of ceftriaxone or vancomycin in cerebrospinal fluid. Rabbits were inoculated with a penicillin-sensitive strain of Streptococcus pneumoniae and treated with ceftriaxone or vancomycin with or without dexamethasone. In the ceftriaxone-treated groups, no statistically significant differences were seen between the group treated with dexamethasone and that without dexamethasone; however, in the vancomycin-treated groups we found statistically significant lower cerebrospinal fluid vancomycin levels at 2 h in the dexamethasone-treated rabbits and differences in bacterial killing.<\/jats:p>","DOI":"10.1128\/aac.39.9.2158","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T00:06:25Z","timestamp":1340841985000},"page":"2158-2160","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":73,"title":["Influence of dexamethasone on efficacy of ceftriaxone and vancomycin therapy in experimental pneumococcal meningitis"],"prefix":"10.1128","volume":"39","author":[{"given":"C","family":"Cabellos","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Ciutat Sanit\u00e0ria i Universit\u00e0ria de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Martinez-Lacasa","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ciutat Sanit\u00e0ria i Universit\u00e0ria de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Martos","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ciutat Sanit\u00e0ria i Universit\u00e0ria de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Tubau","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ciutat Sanit\u00e0ria i Universit\u00e0ria de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ciutat Sanit\u00e0ria i Universit\u00e0ria de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P F","family":"Viladrich","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ciutat Sanit\u00e0ria i Universit\u00e0ria de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Gudiol","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Ciutat Sanit\u00e0ria i Universit\u00e0ria de Bellvitge, Barcelona, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.39.9.2158","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.39.9.2158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:05:28Z","timestamp":1645473928000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.39.9.2158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1128\/AAC.39.9.2158"],"URL":"https:\/\/doi.org\/10.1128\/aac.39.9.2158","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]},"assertion":[{"value":"1995-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}