{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:47:44Z","timestamp":1767167264649,"version":"build-2238731810"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1973,11,1]],"date-time":"1973-11-01T00:00:00Z","timestamp":120960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1973,11]]},"abstract":"<jats:p>Clindamycin palmitate and potassium phenoxymethyl penicillin were evaluated in 103 children with upper respiratory illnesses and pharyngeal group A streptococci, from November 1970 to July 1971. The children were assigned randomly by weight to one of the antibiotic regimens given orally for 10 days. Clindamycin palmitate and potassium phenoxymethyl penicillin dosages were 75 and 125 mg, respectively, in 5 ml tid for children weighing less than 25 kg, and 150 and 250 mg, respectively, in 10 ml bid for children weighing 25 kg or more. Recurrences of the original streptococcal group A, M, and T types within 3 weeks after the end of treatment were classified as failures. The failure rates were: clindamycin palmitate, 10% (5 of 52), and potassium phenoxymethyl penicillin, 18% (9 of 51). Possible drug-related rashes were observed in 8 of 52 clindamycin palmitate-treated patients. The geometric mean minimal inhibitory concentrations of clindamycin and penicillin against 103 isolates of group A streptococci were 0.033 and 0.007 \u03bcg\/ml, respectively. The serum concentrations about 70 min after ingesting 150 mg of clindamycin palmitate averaged 3.8 \u03bcg\/ml and after 250 mg of potassium phenoxymethyl penicillin averaged 0.9 \u03bcg\/ml. Clindamycin palmitate was as effective as potassium phenoxymethyl penicillin in eradicating group A streptococci from the pharynx in tid and bid regimens. Nevertheless, because of its rash-producing tendency in some patients and higher cost, clindamycin palmitate should not be preferred to penicillin for treatment of streptococcal sore throat in the non-penicillin-allergic patient.<\/jats:p>","DOI":"10.1128\/aac.4.5.514","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T19:57:02Z","timestamp":1340827022000},"page":"514-520","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":30,"title":["Streptococcal Pharyngitis Therapy: Comparison of Clindamycin Palmitate and Potassium Phenoxymethyl Penicillin"],"prefix":"10.1128","volume":"4","author":[{"given":"Maxwell","family":"Stillerman","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Laboratories, Long Island Jewish-Hillside Medical Center, New Hyde Park, New York 11040"},{"name":"Center for Disease Control, Atlanta, Georgia 30333"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry D.","family":"Isenberg","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Laboratories, Long Island Jewish-Hillside Medical Center, New Hyde Park, New York 11040"},{"name":"Center for Disease Control, Atlanta, Georgia 30333"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard R.","family":"Facklam","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Laboratories, Long Island Jewish-Hillside Medical Center, New Hyde Park, New York 11040"},{"name":"Center for Disease Control, Atlanta, Georgia 30333"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","updated-by":[{"DOI":"10.1128\/aac.5.2.202-a","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[1974,2,1]],"date-time":"1974-02-01T00:00:00Z","timestamp":128908800000}}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.4.5.514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.4.5.514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T09:21:33Z","timestamp":1645435293000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.4.5.514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,11]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1973,11]]}},"alternative-id":["10.1128\/AAC.4.5.514"],"URL":"https:\/\/doi.org\/10.1128\/aac.4.5.514","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,11]]},"assertion":[{"value":"1973-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}