{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T16:47:24Z","timestamp":1649177244480},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1996,1,1]],"date-time":"1996-01-01T00:00:00Z","timestamp":820454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:p>The intestinal elimination of ciprofloxacin in the large bowel was studied in a rabbit model. Segments from the cecum, colon, and sigmoid colon along with their intact blood vessels were isolated and perfused, and their contents were collected over a 90-min period following the administration of a single parenteral dose of 27 mg of ciprofloxacin per kg of body weight. The elimination rates of ciprofloxacin were 0.126 +\/- 0.084 micrograms.min-1.cm-2 in the cecum and 0.264 +\/- 0.126, 0.11 +\/- 0.07, and 0.21 +\/- 0.141 micrograms.min-1.cm-2 in the proximal colon, distal colon, and sigmoid colon, respectively. The calculated fraction of ciprofloxacin eliminated in the large bowel was 3% of the parenteral dose administered. The elimination pattern of ciprofloxacin in the large bowel may explain the unusual activity of this fluoroquinolone in modifying the colonic flora.<\/jats:p>","DOI":"10.1128\/aac.40.1.11","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:24:34Z","timestamp":1539044674000},"page":"11-13","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":3,"title":["Excretion of ciprofloxacin into the large bowel of the rabbit"],"prefix":"10.1128","volume":"40","author":[{"given":"J","family":"Ramon","sequence":"first","affiliation":[{"name":"Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Dautrey","sequence":"additional","affiliation":[{"name":"Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Farinoti","sequence":"additional","affiliation":[{"name":"Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Carbon","sequence":"additional","affiliation":[{"name":"Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"Chaim Sheba Medical Center, Tel-Aviv University School of Medicine, Tel-Hashomer, Israel."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.1.11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.1.11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:59:59Z","timestamp":1645473599000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.40.1.11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["10.1128\/AAC.40.1.11"],"URL":"https:\/\/doi.org\/10.1128\/aac.40.1.11","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1]]},"assertion":[{"value":"1996-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}