{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:26Z","timestamp":1791262586322,"version":"4.1.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1996,1,1]],"date-time":"1996-01-01T00:00:00Z","timestamp":820454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:p>Following successful chemotherapy in canine visceral leishmaniasis, monocyte-derived macrophages can induce antileishmanial activity via a gamma interferon-dependent mechanism in the presence of autologous lymphocytes. The killing of leishmania correlated with the induction of the NO synthase pathway, because it correlated with the generation of nitrogen derivative production and was abrogated in the presence of NG-monomethyl-L-arginine, a competitive inhibitor of the NO synthase pathway. The level of L-citrulline in serum, which was produced after activation of the NO synthase pathway, was markedly enhanced in dogs receiving successful chemotherapy. Taken together, these data indicate that following successful chemotherapy of visceral leishmaniasis, leishmania parasites are killed by macrophages activated by gamma interferon-producing lymphocytes via an NO-dependent mechanism.<\/jats:p>","DOI":"10.1128\/aac.40.1.253","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:24:34Z","timestamp":1539044674000},"page":"253-256","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":48,"title":["Canine visceral leishmaniasis: successful chemotherapy induces macrophage antileishmanial activity via the L-arginine nitric oxide pathway"],"prefix":"10.1128","volume":"40","author":[{"given":"I","family":"Vouldoukis","sequence":"first","affiliation":[{"name":"Laboratoire de Parasitologie Experimentale, Facult\u00e9 de M\u00e9decine Piti\u00e9 Salp\u00e9tri\u00e8re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Drapier","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie Experimentale, Facult\u00e9 de M\u00e9decine Piti\u00e9 Salp\u00e9tri\u00e8re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A K","family":"N\u00fcssler","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie Experimentale, Facult\u00e9 de M\u00e9decine Piti\u00e9 Salp\u00e9tri\u00e8re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Tselentis","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie Experimentale, Facult\u00e9 de M\u00e9decine Piti\u00e9 Salp\u00e9tri\u00e8re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O A","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie Experimentale, Facult\u00e9 de M\u00e9decine Piti\u00e9 Salp\u00e9tri\u00e8re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Gentilini","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie Experimentale, Facult\u00e9 de M\u00e9decine Piti\u00e9 Salp\u00e9tri\u00e8re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D M","family":"Mossalayi","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie Experimentale, Facult\u00e9 de M\u00e9decine Piti\u00e9 Salp\u00e9tri\u00e8re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Monjour","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie Experimentale, Facult\u00e9 de M\u00e9decine Piti\u00e9 Salp\u00e9tri\u00e8re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Dugas","sequence":"additional","affiliation":[{"name":"Laboratoire de Parasitologie Experimentale, Facult\u00e9 de M\u00e9decine Piti\u00e9 Salp\u00e9tri\u00e8re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.1.253","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.1.253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:59:41Z","timestamp":1645473581000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.40.1.253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["10.1128\/AAC.40.1.253"],"URL":"https:\/\/doi.org\/10.1128\/aac.40.1.253","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1]]},"assertion":[{"value":"1996-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}