{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:15:44Z","timestamp":1770488144358,"version":"3.49.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[1996,11,1]],"date-time":"1996-11-01T00:00:00Z","timestamp":846806400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1996,11]]},"abstract":"The antileishmanial efficacies of 2-n-propylquinoline, chimanines B and D, 2-n-pentylquinoline, 2-phenylquinoline, 2-(3,4-methylenedioxyphenylethyl) quinoline, and two total alkaloidal extracts of Galipea longiflora were evaluated in BALB\/c mice infected with Leishmania amazonensis or Leishmania venezuelensis. Animals were treated for 4 to 6 weeks postinfection with a quinoline by the oral route at 50 mg\/kg of body weight twice daily for 15 days or by five intralesional injections at intervals of 4 days with a quinoline at 50 mg\/kg of body weight. The reference drug, N-methylglucamine antimonate (Glucantime), was administered by subcutaneous or intralesional injection (regimens of 14, 28, or 56 mg of pentavalent antimony [Sbv] per kg of body weight daily). Twice-daily oral treatment with chimanine B at 50 mg\/kg resulted in a decrease in lesion weight by 70% (P < 0.001) and a decrease in the parasite loads by 95% (P < 0.001). Five injections of chimanine B at intervals of 4 days reduced the lesion weight by 74% and the parasite loads in the lesion by 90% compared with the values for the group of untreated mice. Subcutaneous administration of N-methylglucamine antimonate at 28 mg of Sbv kg per day for 15 days reduced the parasite burden by 95% (P < 0.001), and five intralesional injections at the same concentration reduced the parasite burden by 96% (P < 0.001). Other 2-substituted quinolines, 2-n-propylquinoline administered by the oral and intralesional routes, 2-phenylquinoline administered by the oral route, 2-n-pentylquinoline administered by intralesional injection, and two total alkaloidal extracts of G. longiflora administered by the oral route, had intermediate effects. These findings suggest that chimanine B may be chosen as a lead molecule in the development of oral therapy against leishmaniasis.<\/jats:p>","DOI":"10.1128\/aac.40.11.2447","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:24:18Z","timestamp":1539044658000},"page":"2447-2451","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":97,"title":["In vivo efficacy of oral and intralesional administration of 2-substituted quinolines in experimental treatment of new world cutaneous leishmaniasis caused by Leishmania amazonensis"],"prefix":"10.1128","volume":"40","author":[{"given":"A","family":"Fournet","sequence":"first","affiliation":[{"name":"ORSTOM, Institut Fran\u00e7ais de Recherche Scientifique pour le D\u00e9veloppement en Coop\u00e9ration, Asunci\u00f3n, Paraguay. fournet@ui131.una.py"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"Ferreira","sequence":"additional","affiliation":[{"name":"ORSTOM, Institut Fran\u00e7ais de Recherche Scientifique pour le D\u00e9veloppement en Coop\u00e9ration, Asunci\u00f3n, Paraguay. fournet@ui131.una.py"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Rojas De Arias","sequence":"additional","affiliation":[{"name":"ORSTOM, Institut Fran\u00e7ais de Recherche Scientifique pour le D\u00e9veloppement en Coop\u00e9ration, Asunci\u00f3n, Paraguay. fournet@ui131.una.py"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Torres De Ortiz","sequence":"additional","affiliation":[{"name":"ORSTOM, Institut Fran\u00e7ais de Recherche Scientifique pour le D\u00e9veloppement en Coop\u00e9ration, Asunci\u00f3n, Paraguay. fournet@ui131.una.py"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Fuentes","sequence":"additional","affiliation":[{"name":"ORSTOM, Institut Fran\u00e7ais de Recherche Scientifique pour le D\u00e9veloppement en Coop\u00e9ration, Asunci\u00f3n, Paraguay. fournet@ui131.una.py"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Nakayama","sequence":"additional","affiliation":[{"name":"ORSTOM, Institut Fran\u00e7ais de Recherche Scientifique pour le D\u00e9veloppement en Coop\u00e9ration, Asunci\u00f3n, Paraguay. fournet@ui131.una.py"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Schinini","sequence":"additional","affiliation":[{"name":"ORSTOM, Institut Fran\u00e7ais de Recherche Scientifique pour le D\u00e9veloppement en Coop\u00e9ration, Asunci\u00f3n, Paraguay. fournet@ui131.una.py"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Hocquemiller","sequence":"additional","affiliation":[{"name":"ORSTOM, Institut Fran\u00e7ais de Recherche Scientifique pour le D\u00e9veloppement en Coop\u00e9ration, Asunci\u00f3n, Paraguay. fournet@ui131.una.py"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.11.2447","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.11.2447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:57:44Z","timestamp":1645473464000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.40.11.2447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,11]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1996,11]]}},"alternative-id":["10.1128\/AAC.40.11.2447"],"URL":"https:\/\/doi.org\/10.1128\/aac.40.11.2447","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,11]]},"assertion":[{"value":"1996-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}