{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:20:29Z","timestamp":1791206429181,"version":"4.1.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[1996,12,1]],"date-time":"1996-12-01T00:00:00Z","timestamp":849398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1996,12]]},"abstract":"<jats:p>As a paradigm for chronic infectious diseases, tuberculosis exhibits a variety of clinical presentations, ranging from primary pulmonary tuberculosis to reactivation tuberculosis and cavitary disease. To date, the animal models used in evaluating chemotherapy of tuberculosis have been high-dose intravenous models that mimic the disseminated forms of the disease. In the present study, we have used a low-dose aerosol exposure model which we feel better reflects newly diagnosed tuberculosis in patients converting to tuberculin positivity. As appropriate examples of chemotherapy, four rifamycins (rifampin, rifabutin, rifapentine, and KRM-1648) were tested, first in an in vitro murine macrophage model and then in the low-dose aerosol infection model, for their activity against Mycobacterium tuberculosis. In both models, KRM-1648 had the highest level of activity of the four compounds. In the infected-lung model, rifabutin, rifapentine, and KRM-1648 all had sterilizing activity when given orally at 5 mg\/kg of body weight per day. When given at 2.5 mg\/kg\/day, KRM-1648 had the highest level of activity of the four drugs, reducing the bacterial load by 2.7 logs over 35 days of therapy.<\/jats:p>","DOI":"10.1128\/aac.40.12.2809","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:24:25Z","timestamp":1539044665000},"page":"2809-2812","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":98,"title":["Low-dose aerosol infection model for testing drugs for efficacy against Mycobacterium tuberculosis"],"prefix":"10.1128","volume":"40","author":[{"given":"B P","family":"Kelly","sequence":"first","affiliation":[{"name":"Department of Microbiology, Colorado State University, Fort Collins 80523, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S K","family":"Furney","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Colorado State University, Fort Collins 80523, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"Jessen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Colorado State University, Fort Collins 80523, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I M","family":"Orme","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Colorado State University, Fort Collins 80523, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.12.2809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.12.2809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:03:49Z","timestamp":1645473829000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.40.12.2809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1996,12]]}},"alternative-id":["10.1128\/AAC.40.12.2809"],"URL":"https:\/\/doi.org\/10.1128\/aac.40.12.2809","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,12]]},"assertion":[{"value":"1996-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}