{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:46:23Z","timestamp":1772689583648,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1996,2,1]],"date-time":"1996-02-01T00:00:00Z","timestamp":823132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p>The in vitro and in vivo activities of a new rifamycin derivative, KRM-1648, against Mycobacterium tuberculosis H37Rv were compared with those of rifampin. Bactericidal activity was evaluated by using a silicone-coated slide culture method. The MBC of KRM-1648 was 0.15 to 0.3 microgram\/ml for 24 h of exposure, while that of rifampin was &gt; 160 microgram\/ml under the same conditions. Against experimental murine tuberculosis, KRM-1648 exhibited significant therapeutic effects, in terms of prolonged survival times for mice compared with those with rifampin treatment, even at lower doses, such as 1 and 3 mg\/kg. At a dose of 3 mg\/kg, KRM-1648 was at least as effective as rifampin at 10 mg\/kg. The combination of KRM-1648 (3 mg\/kg) plus isoniazid (3 mg\/kg) plus ethambutol (10 mg\/kg) exhibited much more activity than did rifampin (10 mg\/kg) plus isoniazid (3 mg\/kg) plus ethambutol (10 mg\/kg). These findings suggest that KRM-1648 is a promising candidate for the treatment of tuberculosis.<\/jats:p>","DOI":"10.1128\/aac.40.2.426","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:24:50Z","timestamp":1539044690000},"page":"426-428","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["In vitro bactericidal and in vivo therapeutic activities of a new rifamycin derivative, KRM-1648, against Mycobacterium tuberculosis"],"prefix":"10.1128","volume":"40","author":[{"given":"T","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Infection and Inflammation, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Amitani","sequence":"additional","affiliation":[{"name":"Department of Infection and Inflammation, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Infection and Inflammation, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Infection and Inflammation, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Murayama","sequence":"additional","affiliation":[{"name":"Department of Infection and Inflammation, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Kuze","sequence":"additional","affiliation":[{"name":"Department of Infection and Inflammation, Kyoto University, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.2.426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.2.426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:05:57Z","timestamp":1645473957000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.40.2.426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["10.1128\/AAC.40.2.426"],"URL":"https:\/\/doi.org\/10.1128\/aac.40.2.426","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2]]},"assertion":[{"value":"1996-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}