{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T02:36:46Z","timestamp":1789353406336,"version":"build-2803163510"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:p>Two new fluorinated oxazolidinones, U-100592 and U-100766, were evaluated against more than 659 gram-positive and -negative organisms and compared with glycopeptides, erythromycin, clindamycin, clinafloxacin, and chloramphenicol. U-100592 and U-100766 were usually equally potent, but the MICs at which 90% of the isolates are inhibited (MIC90s) of U-100592 for some staphylococci and enterococci were slightly lower than those of U-100766 (1 versus 2 micrograms\/ml). The MIC90 of U-100592 and U-100766 for oxacillin-resistant Staphylococcus aureus was 2 micrograms\/ml, the same as observed for oxacillin-susceptible strains. The oxazolidinone MICs for other Staphylococcus spp. were &lt; or = 2 micrograms\/ml (MIC50, 0.5 to 1 microgram\/ml). All enterococci were inhibited by &lt; or = 4 and &lt; or = 2 micrograms of U-100592 and U-100766 per ml, respectively. Against 152 vancomycin-resistant enterococci (five species), both compounds had a narrow range of MICs (0.25 to 2 micrograms\/ml) and a MIC90 of 1 microgram\/ml. Corynebacterium jeikeium, Bacillus spp., and all tested streptococci were inhibited (&lt; or = 4 micrograms\/ml). Members of the family Enterobacteriaceae and other gram-negative bacilli were not susceptible (MIC50, &gt; 64 micrograms\/ml) to either oxazolidinone. Three potencies of U-100592 and U-100766 disks were tested (5, 15, and 30 micrograms), and acceptable correlations (r = 0.81 to 0.90) with the measured MICs were observed. Best discrimination of the tentatively susceptible organisms (MICs, &lt; or = 4 micrograms\/ml) was demonstrated with the 30-micrograms disk concentration. The oxazolidinones demonstrated a dominant bacteristatic action. These oxazolidinones (U-100592 and U-100766) appear promising for treatment of gram-positive organisms that demonstrate resistance to contemporary therapeutic agents.<\/jats:p>","DOI":"10.1128\/aac.40.3.720","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:25:03Z","timestamp":1539044703000},"page":"720-726","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":104,"title":["In vitro antimicrobial activities and spectra of U-100592 and U-100766, two novel fluorinated oxazolidinones"],"prefix":"10.1128","volume":"40","author":[{"given":"R N","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D M","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"Erwin","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.3.720","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.3.720","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:04:01Z","timestamp":1645473841000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.40.3.720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["10.1128\/AAC.40.3.720"],"URL":"https:\/\/doi.org\/10.1128\/aac.40.3.720","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]},"assertion":[{"value":"1996-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}