{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:25:53Z","timestamp":1762867553356},"reference-count":0,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1996,4,1]],"date-time":"1996-04-01T00:00:00Z","timestamp":828316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:p>The efficacy and safety of a 3-day course of azithromycin oral suspension (10 mg\/kg of body weight once daily) were compared with those of penicillin V (50,000 U\/kg\/day in two divided doses) in children aged 3 to 12 years for the treatment of symptomatic pharyngitis caused by the group A beta-hemolytic streptococcus (GABHS). For the 154 evaluable patients, the original infecting strain of GABHS was eliminated at the end of follow-up (34 to 36 days after treatment started) from 67 (85.8%) of 78 penicillin-treated patients and 41 (53.9%) of 76 azithromycin-treated patients (P &lt; 0.0001). Overall clinical success was achieved in 71 (91.0%) of 78 penicillin V-treated patients and 57 (75.0%) of 76 azithromycin-treated patients (P &lt; 0.05). Potential drug-related adverse events were reported for 5.5 and 8.6% of the penicillin V- and azithromycin-treated patients, respectively (P = 0.6). In the present study, a once-daily (10 mg\/kg), 3-day oral regimen of azithromycin was as safe as a 10-day course of penicillin but did not represent an effective alternative to penicillin for the treatment of GABHS pharyngitis, even for those children with azithromycin-susceptible strains.<\/jats:p>","DOI":"10.1128\/aac.40.4.1005","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:25:14Z","timestamp":1539044714000},"page":"1005-1008","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["Comparative efficacy and safety of 3-day azithromycin and 10-day penicillin V treatment of group A beta-hemolytic streptococcal pharyngitis in children"],"prefix":"10.1128","volume":"40","author":[{"given":"L","family":"Pacifico","sequence":"first","affiliation":[{"name":"Institute of Pediatrics, La Sapienza University of Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Scopetti","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics, La Sapienza University of Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Ranucci","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics, La Sapienza University of Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pataracchia","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics, La Sapienza University of Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Savignoni","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics, La Sapienza University of Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Chiesa","sequence":"additional","affiliation":[{"name":"Institute of Pediatrics, La Sapienza University of Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.4.1005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.4.1005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:00:27Z","timestamp":1645473627000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.40.4.1005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["10.1128\/AAC.40.4.1005"],"URL":"https:\/\/doi.org\/10.1128\/aac.40.4.1005","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4]]},"assertion":[{"value":"1996-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}