{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:53:01Z","timestamp":1771674781355,"version":"3.50.1"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[1996,9,1]],"date-time":"1996-09-01T00:00:00Z","timestamp":841536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1996,9]]},"abstract":"<jats:p>We used a gerbil model of otitis media to assess the efficacy of single-dose ceftriaxone against three Streptococcus pneumoniae strains highly resistant to penicillin (MICs, 4 to 8 micrograms\/ml) and with various susceptibilities to ceftriaxone (MICs, 0.5, 4, and 8 micrograms\/ml). Middle ear infection was induced by bilateral transbullar challenge with 10(7) bacteria per ear. Antibiotic treatment was administered subcutaneously at 2 h postinfection. Infection status was checked 2 days later by counting the bacteria in middle ear and cerebrospinal fluid samples. With the cefriaxone-susceptible strain (MIC, 0.5 microgram\/ml), we tested doses of 5 to 100 mg\/kg of body weight. With a dose of 50 mg\/kg, treatment outcome was equivalent to that with amoxicillin, which was used as a reference (25 mg\/kg, two injections); no bacteria were recovered from 82% of the middle ear samples, and the rate of cerebrospinal fluid culture positivity was significantly reduced to 6%, relative to 59% for the untreated controls. Similar efficacy was obtained with a dose of 100 mg\/kg against the two ceftriaxone-resistant strains. Pharmacokinetic study indicates that the values of the parameters in plasma after the administration of a dose of 100 mg\/kg (peak level of total drug, 268 +\/- 33 micrograms\/ml; elimination half-life, 0.8 h; area under concentration-time curve, 488 micrograms.h.ml-1) were still suboptimal compared with the values of the parameters measured in pediatric patients after intravenous or intramuscular administration of a dose of 50 mg\/kg. Our results indicate the efficacy of ceftriaxone against experimental cephalosporin-resistant pneumococcal otitis and provide a basis for the clinical use of single-dose ceftriaxone against pneumococcal otitis media.<\/jats:p>","DOI":"10.1128\/aac.40.9.1977","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T20:26:50Z","timestamp":1539030410000},"page":"1977-1982","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy of single-dose ceftriaxone in experimental otitis media induced by penicillin- and cephalosporin-resistant Streptococcus pneumoniae"],"prefix":"10.1128","volume":"40","author":[{"given":"B","family":"Barry","sequence":"first","affiliation":[{"name":"Unit\u00e9 13, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, H\u00f4pital Bichat-Claude Bernard, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Muffat-Joly","sequence":"additional","affiliation":[{"name":"Unit\u00e9 13, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, H\u00f4pital Bichat-Claude Bernard, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Bauchet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 13, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, H\u00f4pital Bichat-Claude Bernard, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Faurisson","sequence":"additional","affiliation":[{"name":"Unit\u00e9 13, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, H\u00f4pital Bichat-Claude Bernard, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Gehanno","sequence":"additional","affiliation":[{"name":"Unit\u00e9 13, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, H\u00f4pital Bichat-Claude Bernard, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Pocidalo","sequence":"additional","affiliation":[{"name":"Unit\u00e9 13, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, H\u00f4pital Bichat-Claude Bernard, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Carbon","sequence":"additional","affiliation":[{"name":"Unit\u00e9 13, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, H\u00f4pital Bichat-Claude Bernard, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","updated-by":[{"DOI":"10.1128\/aac.40.12.2911","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[1996,12,1]],"date-time":"1996-12-01T00:00:00Z","timestamp":849398400000}}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.9.1977","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.40.9.1977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:09:32Z","timestamp":1645456172000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.40.9.1977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1996,9]]}},"alternative-id":["10.1128\/AAC.40.9.1977"],"URL":"https:\/\/doi.org\/10.1128\/aac.40.9.1977","relation":{"correction":[{"id-type":"doi","id":"10.1128\/AAC.40.12.2911","asserted-by":"object"}]},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,9]]},"assertion":[{"value":"1996-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}