{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:57:42Z","timestamp":1761490662509},"reference-count":0,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:p>5'-Deoxy-5'-(methylthio)adenosine (MTA), a key by-product of polyamine biosynthesis, is cleaved by MTA phosphorylase and is salvaged as adenine and, through conversion of the ribose moiety, methionine. An analog of MTA, 5'-deoxy-5'-(hydroxyethylthio)adenosine (HETA), is a substrate for trypanosome MTA phosphorylase and is active in vitro and in vivo against Trypanosoma brucei brucei, an agent of bovine trypanosomiasis. In this study, HETA and three O-acylated HETA derivatives were examined for their activities against model infections of T. b. brucei and Trypanosoma brucei rhodesiense, the agent of East African sleeping sickness. HETA was curative (&gt;60%) for infections caused by 5 of 11 clinical isolates of T. b. rhodesiense when it was given to mice at 200 mg\/kg of body weight for 7 days as a continuous infusion in osmotic pumps. HETA at 150 to 200 mg\/kg also extended the life spans of the mice infected with four additional isolates two- to fivefold. Di- and tri-O-acetylated derivatives of HETA also proved curative for the infections, while a tri-O-propionyl derivative, although also curative, was not as effective. This study indicates that substrate analogs of MTA should be given important consideration for development as novel chemotherapies against African trypanosomiasis.<\/jats:p>","DOI":"10.1128\/aac.41.10.2108","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:27:03Z","timestamp":1539044823000},"page":"2108-2112","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["In vivo efficacies of 5'-methylthioadenosine analogs as trypanocides"],"prefix":"10.1128","volume":"41","author":[{"given":"C J","family":"Bacchi","sequence":"first","affiliation":[{"name":"Department of Biology, Pace University, New York, New York 10038, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Sanabria","sequence":"additional","affiliation":[{"name":"Department of Biology, Pace University, New York, New York 10038, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Spiess","sequence":"additional","affiliation":[{"name":"Department of Biology, Pace University, New York, New York 10038, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Biology, Pace University, New York, New York 10038, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"C J","family":"Marasco","sequence":"additional","affiliation":[{"name":"Department of Biology, Pace University, New York, New York 10038, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L M","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Department of Biology, Pace University, New York, New York 10038, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Department of Biology, Pace University, New York, New York 10038, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Sufrin","sequence":"additional","affiliation":[{"name":"Department of Biology, Pace University, New York, New York 10038, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.41.10.2108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.41.10.2108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:10:10Z","timestamp":1645474210000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.41.10.2108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["10.1128\/AAC.41.10.2108"],"URL":"https:\/\/doi.org\/10.1128\/aac.41.10.2108","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]},"assertion":[{"value":"1997-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}