{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:29:41Z","timestamp":1783002581395,"version":"3.54.5"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:p>CFC-222 is a novel fluoroquinolone containing a C-7 bicyclic amine moiety with potent antibacterial activities against gram-positive, gram-negative, and anaerobic organisms. We compared the in vitro and in vivo activities of CFC-222 with those of ciprofloxacin, ofloxacin, and lomefloxacin. CFC-222 was more active than the other fluoroquinolones tested against gram-positive bacteria. CFC-222 was particularly active against Streptococcus pneumoniae (MIC at which 90% of isolates are inhibited [MIC90], 0.2 microg\/ml), Staphylococcus aureus (MIC90, 0.2 microg\/ml for ciprofloxacin-susceptible strains), and Enterococcus faecalis (MIC90, 0.39 microg\/ml). Against Escherichia coli and other members of the family Enterobacteriaceae, CFC-222 was slightly less active than ciprofloxacin (MIC90s for E. coli, 0.1 and 0.025 microg\/ml, respectively). The in vitro activity of CFC-222 was not influenced by inoculum size, medium composition, or the presence of horse serum. However, its activity was decreased significantly by a change in the pH of the medium from 7.0 to 6.0, as was the case for the other quinolones tested. The in vivo protective efficacy of CFC-222 by oral administration was greater than those of the other quinolones tested in a mouse model of intraperitoneally inoculated systemic infection caused by S. aureus. CFC-222 exhibited efficacy comparable to that of ciprofloxacin in the same model of infection caused by gram-negative organisms, such as E. coli and Klebsiella pneumoniae. In this infection model, CFC-222 was slightly less active than ciprofloxacin against Pseudomonas aeruginosa. These results suggest that CFC-222 may be a promising therapeutic agent in various bacterial infections.<\/jats:p>","DOI":"10.1128\/aac.41.10.2209","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:27:03Z","timestamp":1539044823000},"page":"2209-2213","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["In vitro and in vivo antibacterial efficacies of CFC-222, a new fluoroquinolone"],"prefix":"10.1128","volume":"41","author":[{"given":"J H","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Microbial Chemistry, College of Pharmacy, Seoul National University, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Microbial Chemistry, College of Pharmacy, Seoul National University, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y G","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbial Chemistry, College of Pharmacy, Seoul National University, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J W","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbial Chemistry, College of Pharmacy, Seoul National University, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbial Chemistry, College of Pharmacy, Seoul National University, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E C","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Microbial Chemistry, College of Pharmacy, Seoul National University, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B K","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbial Chemistry, College of Pharmacy, Seoul National University, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.41.10.2209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.41.10.2209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:10:15Z","timestamp":1645474215000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.41.10.2209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["10.1128\/AAC.41.10.2209"],"URL":"https:\/\/doi.org\/10.1128\/aac.41.10.2209","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]},"assertion":[{"value":"1997-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}