{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T01:24:19Z","timestamp":1770513859175,"version":"3.49.0"},"reference-count":0,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>Nikkomycin Z is a chitin synthetase inhibitor. In vitro, nikkomycin Z had good activity against Blastomyces dermatitidis, with an MIC of 0.78 microg\/ml and a minimal fungicidal concentration of 3.1 microg\/ml. The efficacies of various treatment durations (3, 5, or 10 days) and doses (200, 400, or 1,000 mg\/kg of body weight) of nikkomycin Z given twice daily were compared with those of itraconazole at 200 mg\/kg given twice daily and amphotericin B at 6.25 mg\/kg in a murine model of pulmonary blastomycosis. All treatments prolonged survival compared with untreated controls (P &lt; 0.05 to 0.01); 100% survival was achieved with 5 or 10 days of any nikkomycin Z dose or with amphotericin B. Amphotericin B and nikkomycin Z, but not itraconazole, reduced infection compared with controls. Amphotericin B and the 10-day regimens of all nikkomycin Z doses were equivalent and superior to itraconazole or nikkomycin Z for &lt; or = 5 days at any dose (P &lt; 0.05 to 0.01). Increased duration and\/or dosage improved the efficacy of nikkomycin Z, with 10 days of each dose curing 50 to 90% of the animals. Only a 1,000-mg\/kg\/day dose of nikkomycin Z was curative when treatment lasted less than 10 days. In contrast, itraconazole cured no mice, while amphotericin B cured all mice. Based on the total amount of drug given, amphotericin B was estimated to be 32 times as active as nikkomycin Z and nikkomycin Z was estimated to be 3 times as active as itraconazole. Overall, nikkomycin Z given orally was well tolerated, had good activity against blastomycosis, and could result in biological cure, thus producing results equivalent to those of parenteral amphotericin B.<\/jats:p>","DOI":"10.1128\/aac.41.9.2026","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:29:17Z","timestamp":1539044957000},"page":"2026-2028","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["Efficacy of nikkomycin Z against experimental pulmonary blastomycosis"],"prefix":"10.1128","volume":"41","author":[{"given":"K V","family":"Clemons","sequence":"first","affiliation":[{"name":"California Institute for Medical Research, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128, USA. id.cimr@juno.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Stevens","sequence":"additional","affiliation":[{"name":"California Institute for Medical Research, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128, USA. id.cimr@juno.com"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.41.9.2026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.41.9.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:14:12Z","timestamp":1645474452000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.41.9.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1128\/AAC.41.9.2026"],"URL":"https:\/\/doi.org\/10.1128\/aac.41.9.2026","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]},"assertion":[{"value":"1997-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}