{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:26:05Z","timestamp":1762867565238},"reference-count":0,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>An Escherichia coli strain resistant to a broad spectrum of beta-lactams, including cephamycins, was isolated from a patient suffering from urinary tract infection. A resistance plasmid (pMVP-7) was transferred from the clinical isolate to an Escherichia coli recipient. Both strains produce a cefoxitin-hydrolyzing beta-lactamase focusing at pI 6.7. The phenotype was similar to that of a Klebsiella pneumoniae strain producing cephamycinase FOX-1, so primers were selected from the FOX-1 sequence to amplify the bla gene of the transconjugant. The PCR product obtained was sequenced. The percentage of identity of the deduced amino acid sequence with sequences of other AmpC-type beta-lactamases was 96.9% with FOX-1, 74.9% with CMY-1, and 67.7% with MOX-1. This new plasmid-mediated enzyme is most closely related to FOX-1 (11 amino acid exchanges). We therefore propose the designation FOX-2.<\/jats:p>","DOI":"10.1128\/aac.41.9.2041","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:29:17Z","timestamp":1539044957000},"page":"2041-2046","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":44,"title":["A novel class C beta-lactamase (FOX-2) in Escherichia coli conferring resistance to cephamycins"],"prefix":"10.1128","volume":"41","author":[{"given":"A","family":"Bauernfeind","sequence":"first","affiliation":[{"name":"Max von Pettenkofer-Institut, Munich, Federal Republic of Germany. Adolf.Bauernfeind@mvp-bak.med.uni-muenchen.de"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Wagner","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer-Institut, Munich, Federal Republic of Germany. Adolf.Bauernfeind@mvp-bak.med.uni-muenchen.de"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Jungwirth","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer-Institut, Munich, Federal Republic of Germany. Adolf.Bauernfeind@mvp-bak.med.uni-muenchen.de"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Schneider","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer-Institut, Munich, Federal Republic of Germany. Adolf.Bauernfeind@mvp-bak.med.uni-muenchen.de"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Meyer","sequence":"additional","affiliation":[{"name":"Max von Pettenkofer-Institut, Munich, Federal Republic of Germany. Adolf.Bauernfeind@mvp-bak.med.uni-muenchen.de"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.41.9.2041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.41.9.2041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:13:24Z","timestamp":1645474404000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.41.9.2041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1128\/AAC.41.9.2041"],"URL":"https:\/\/doi.org\/10.1128\/aac.41.9.2041","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]},"assertion":[{"value":"1997-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}