{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:24:14Z","timestamp":1770337454002,"version":"3.49.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            BALB\/c\n            <jats:italic>nu<\/jats:italic>\n            \/+ immunocompetent and athymic (\n            <jats:italic>nu\/nu<\/jats:italic>\n            ) mice were infected intravenously with yeast cells of\n            <jats:italic>Histoplasma capsulatum<\/jats:italic>\n            . Mice were either given water (controls) intraperitoneally (i.p.) or given MK-991 i.p. once daily or twice daily. Protection was measured as prolonged survival or reduction in tissue counts. MK-991 was protective in immunocompetent mice, prolonging survival and reducing counts in spleen and livers at a dose as low as 0.05 mg\/kg of body weight\/day. MK-991 was modestly effective in athymic mice at a higher dose, 5 mg\/kg\/day. These studies suggest that MK-991 may be appropriate for clinical development in histoplasmosis.\n          <\/jats:p>","DOI":"10.1128\/aac.42.1.151","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:30:08Z","timestamp":1539045008000},"page":"151-153","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["Treatment of Histoplasmosis with MK-991 (L-743,872)"],"prefix":"10.1128","volume":"42","author":[{"given":"John R.","family":"Graybill","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->The University of Texas Health Science Center at San Antonio,1 and"},{"name":"<!--label omitted: 2-->South Texas Veterans Health Care System, Audie Murphy Division,2 San Antonio, Texas 78284"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura K.","family":"Najvar","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->The University of Texas Health Science Center at San Antonio,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor M.","family":"Montalbo","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->The University of Texas Health Science Center at San Antonio,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco J.","family":"Barchiesi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->The University of Texas Health Science Center at San Antonio,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael F.","family":"Luther","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->South Texas Veterans Health Care System, Audie Murphy Division,2 San Antonio, Texas 78284"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->The University of Texas Health Science Center at San Antonio,1 and"},{"name":"<!--label omitted: 2-->South Texas Veterans Health Care System, Audie Murphy Division,2 San Antonio, Texas 78284"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.5.1077"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/15.5.781"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/jac\/33.6.1137","article-title":"The lipopeptide antimycotic cilofungin modulates the incorporation of glucan-associated proteins into the cell wall of Candida albicans","volume":"33","author":"Angiolella L.","year":"1994","unstructured":"Angiolella L. Simonetti N. Cassone A. The lipopeptide antimycotic cilofungin modulates the incorporation of glucan-associated proteins into the cell wall of Candida albicans. J. Antimicrob. Chemother. 33 1994 1137 1146","journal-title":"J. Antimicrob. Chemother."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.5.1070"},{"key":"e_1_3_2_6_2","first-page":"133","article-title":"Correlation of cilofungin in vivo efficacy with its activity against Aspergillus fumigatus (1,3)-\u03b2-d-glucan synthase","volume":"108","author":"Beaulieu D.","year":"1993","unstructured":"Beaulieu D. Tang J. Zeckner D. J. Parr T. R. Jr. Correlation of cilofungin in vivo efficacy with its activity against Aspergillus fumigatus (1,3)-\u03b2-d-glucan synthase. FEMS Microbiol. Lett. 108 1993 133 138","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1056\/NEJM199401273300407","article-title":"Oral azole drugs as systemic antifungal therapy","volume":"330","author":"Como J. A.","year":"1994","unstructured":"Como J. A. Dismukes W. E. Oral azole drugs as systemic antifungal therapy. N. Engl. J. Med. 330 1994 263 272","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_8_2","unstructured":"Espinel-Ingroff\nA.\nIn vitro studies with L-743 872 a water soluble pneumocandin: a comparative study abstr. F31\nAbstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n1996\n105\nAmerican Society for Microbiology\nWashington D.C"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.2.308"},{"key":"e_1_3_2_10_2","first-page":"768","article-title":"Treatment of murine histoplasmosis with UK 49,858 (fluconazole)","volume":"134","author":"Graybill J. R.","year":"1986","unstructured":"Graybill J. R. Palou E. Ahrens J. Treatment of murine histoplasmosis with UK 49,858 (fluconazole). Am. Rev. Respir. Dis. 134 1986 768 770","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_3_2_11_2","unstructured":"Hajdu\nR.\nPelak\nB.\nSundelof\nJ.\nThompson\nR.\nRosen\nH.\nKropp\nH.\nPharmacokinetics of L-743 872 in the mouse rat rhesus and chimpanzee abstr. F44\nAbstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n1996\n107\nAmerican Society for Microbiology\nWashington D.C"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.9.1331"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.12.2005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.12.2750"},{"key":"e_1_3_2_15_2","unstructured":"Merck & Co. Inc. 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