{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:56:35Z","timestamp":1790052995153,"version":"4.0.1"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We investigated the efficacy of long-circulating immunoliposomal amphotericin B (AmB) against invasive pulmonary aspergillosis in mice using three types of liposomal AmB: conventional liposomal AmB (AmBisome), a long-circulating liposomal AmB and prepared by coating the liposome surface with polyethylene glycol (PEG; PEG-L-AmB), long-circulating immunoliposomal AmB (34A-PEG-L-AmB). The survival rates for mice with invasive pulmonary aspergillosis treated with an intravenous dose of 2 mg of AmBisome, PEG-L-AmB, or 34A-PEG-L-AmB per kg of body weight were 16.7, 83.3, and 100%, respectively. Treatment with 34A-PEG-L-AmB produced a marked reduction in the number of\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    organisms in the lungs. Pharmacokinetic studies showed the presence of high AmB concentrations in the plasma of mice treated with PEG-L-AmB (40.8 \u03bcg\/ml) and in the lungs of mice treated with 34A-PEG-L-AmB (42.3 \u03bcg\/g). We conclude that 34A-PEG-L-AmB, a long-circulating immunoliposomal AmB, is a promising form of AmB against invasive pulmonary aspergillosis.\n                  <\/jats:p>","DOI":"10.1128\/aac.42.1.40","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T20:30:08Z","timestamp":1539030608000},"page":"40-44","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Long-Circulating Immunoliposomal Amphotericin B against Invasive Pulmonary Aspergillosis in Mice"],"prefix":"10.1128","volume":"42","author":[{"given":"Takakazu","family":"Otsubo","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Maruyama","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Faculty of Pharmaceutical Science, Teikyo University, Sagamiko, Kanagawa 199-01,2 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigefumi","family":"Maesaki","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitsugu","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitaro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Faculty of Pharmaceutical Science, Teikyo University, Sagamiko, Kanagawa 199-01,2 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Takizawa","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Faculty of Pharmaceutical Science, Teikyo University, Sagamiko, Kanagawa 199-01,2 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunikazu","family":"Moribe","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Faculty of Pharmaceutical Science, Teikyo University, Sagamiko, Kanagawa 199-01,2 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Tomono","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Tashiro","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kohno","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1084\/jem.170.6.2153","article-title":"The immunogenicity of chimeric antibodies","volume":"170","author":"Bruggemann M.","year":"1989","unstructured":"Bruggemann M. 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