{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T20:36:04Z","timestamp":1770150964383,"version":"3.49.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Current therapy for leishmaniasis is unsatisfactory because parenteral antimonial salts and pentamidine are associated with significant toxicity and failure rates. We examined the efficacy of KY62, a new, water-soluble, polyene antifungal, against cutaneous infection with\n            <jats:italic>Leishmania amazonensis<\/jats:italic>\n            and against visceral infection with\n            <jats:italic>Leishmania donovani<\/jats:italic>\n            in susceptible BALB\/c mice. Mice were infected with\n            <jats:italic>L. amazonensis<\/jats:italic>\n            promastigotes in the ear pinna and in the tail and were treated with KY62 or amphotericin B. The cutaneous lesions showed a remarkable response to therapy with KY62 at a dose of 30 mg per kg of body weight per day. At this dose, the efficacy of KY62 was equivalent to or better than that of amphotericin B at 1 to 5 mg\/kg\/day. Mice infected intravenously with 10\n            <jats:sup>7<\/jats:sup>\n            <jats:italic>L. donovani<\/jats:italic>\n            promastigotes and treated with KY62 showed a 4-log reduction in the parasite burden in the liver and spleen compared to untreated mice. These studies indicate potent activity of KY62 against experimental cutaneous leishmaniasis caused by\n            <jats:italic>L. amazoniensis<\/jats:italic>\n            and against experimental visceral leishmaniasis caused by\n            <jats:italic>L. donovani<\/jats:italic>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.42.10.2542","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:29:31Z","timestamp":1539044971000},"page":"2542-2548","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Efficacies of KY62 against\n            <i>Leishmania amazonensis<\/i>\n            and\n            <i>Leishmania donovani<\/i>\n            in Experimental Murine Cutaneous Leishmaniasis and Visceral Leishmaniasis"],"prefix":"10.1128","volume":"42","author":[{"given":"Hail M.","family":"Al-Abdely","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio,1 and"},{"name":"<!--label omitted: 2-->Audie Murphy Veterans Administration Hospital,2 San Antonio, Texas 78284, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Graybill","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio,1 and"},{"name":"<!--label omitted: 2-->Audie Murphy Veterans Administration Hospital,2 San Antonio, Texas 78284, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosie","family":"Bocanegra","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Najvar","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor","family":"Montalbo","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven L.","family":"Regen","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3--> Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 180153"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Melby","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Department of Medicine, The University of Texas Health Science Center at San Antonio,1 and"},{"name":"<!--label omitted: 2-->Audie Murphy Veterans Administration Hospital,2 San Antonio, Texas 78284, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.2.298"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/24.4.684"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1979.28.480"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(96)90270-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.6.938"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/18.1.83"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.1.147"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.1.18-27.1998"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90406-5"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92952-C"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890310070009"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00931097"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1964.11686264"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6124040"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.1.1"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1990.11812446"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900086"},{"key":"e_1_3_2_19_2","first-page":"392","article-title":"The efficacy and safety of ketoconazole in visceral leishmaniasis.","volume":"71","author":"Rashid J. R.","year":"1994","unstructured":"Rashid J. R. Wasunna K. M. Gachihi G. S. Nyakundi P. M. Mbugua J. Kirigi G. The efficacy and safety of ketoconazole in visceral leishmaniasis. East Afr. Med. J. 71 1994 392 395","journal-title":"East Afr. Med. J."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.13.040195.001055"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(95)90476-X"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.1.188"},{"key":"e_1_3_2_23_2","first-page":"644","article-title":"American cutaneous and mucocutaneous leishmaniasis","author":"Walton B. C.","year":"1987","unstructured":"Walton B. C. American cutaneous and mucocutaneous leishmaniasis The leishmaniases in biology and medicine Peters W. Killick-Kendrick R. 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