{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T13:02:45Z","timestamp":1715950965564},"reference-count":24,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Multiple isolates of\n            <jats:italic>Cryptococcus neoformans<\/jats:italic>\n            , including those with fluconazole resistance, were tested to assess the in vitro activity of the new triazole TAK-187. MICs of TAK-187 were at least eightfold lower than those of fluconazole, and fungicidal concentrations for most isolates were 4 \u03bcg\/ml or less. TAK-187 also was evaluated as intermittent therapy using two dosages in a rabbit model of experimental cryptococcal meningitis. Compared to daily treatment with fluconazole, as little as two doses of TAK-187 given 7 days apart were found to be effective. Plasma and cerebrospinal fluid TAK-187 concentrations were many times higher than MICs and fungicidal concentrations. Based upon its therapeutic efficacy and long half-life in the rabbit model, TAK-187 should be investigated for intermittent dosing in treatment or suppression of cryptococcal infections in humans.\n          <\/jats:p>","DOI":"10.1128\/aac.42.10.2630","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:29:31Z","timestamp":1539044971000},"page":"2630-2632","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["In Vitro and In Vivo Efficacy of the Triazole TAK-187 against\n            <i>Cryptococcus neoformans<\/i>"],"prefix":"10.1128","volume":"42","author":[{"given":"Wiley A.","family":"Schell","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Department of Medicine, Duke University Medical Center,1"},{"name":"<!--label omitted: 2-->Veterans Affairs Medical Center,2and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele Madeira Duboc","family":"De Almeida","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Faculdade de Medicina da Universidade de Sa\u0303o Paulo, Sa\u0303o Paulo, Brazil3; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard K.","family":"Dodge","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Duke Cancer Center Biostatistics,4Durham, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Okonogi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->Takeda Chemical Industries, Ltd., Osaka, Japan5"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Perfect","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases, Department of Medicine, Duke University Medical Center,1"},{"name":"<!--label omitted: 2-->Veterans Affairs Medical Center,2and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.6.1337-a"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197907193010303"},{"key":"e_1_3_2_4_2","first-page":"353","article-title":"Azole drug resistance as a cause of clinical relapse in AIDS patients with cryptococcal meningitis.","volume":"6","author":"Birley H. D.","year":"1995","unstructured":"Birley H. D. Johnson E. M. McDonald P. Parry C. Carey P. B. Warnock D. W. Azole drug resistance as a cause of clinical relapse in AIDS patients with cryptococcal meningitis. Int. J. Sex. Transm. Dis. AIDS 6 1995 353 355","journal-title":"Int. J. Sex. Transm. Dis. AIDS"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199102283240902"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198708063170602"},{"key":"e_1_3_2_7_2","unstructured":"Galgiani\n              J. N.\n              Bartlett\n              M. S.\n              Ghannoum\n              M. A.\n              Espinel-Ingroff\n              A.\n              Lancaster\n              M. V.\n              Odds\n              F. C.\n              Pfaller\n              M. A.\n              Rinaldi\n              M. G.\n              Walsh\n              T. J.\n          Reference method for broth dilution antifungal susceptibility testing of yeasts\n          1997\n          1\n          29 Approved standard 17-9. National Committee for Clinical Laboratory Standards Wayne Pa."},{"key":"e_1_3_2_8_2","unstructured":"Itoh\n              K.\n              Okonogi\n              K.\n              Tasaka\n              A.\n              Hayashi\n              R.\n              Tamura\n              N.\n              Tsuchimori\n              N.\n              Kitazaki\n              T.\n              Matsushita\n              Y.\n              Obita\n              J.\n          TAK-187 a new antifungal triazole: synthesis and antifungal activity abstr. F74\n          Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1996\n          112\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_9_2","unstructured":"Pappas\n              P.\n              Perfect\n              J.\n              Henderson\n              H.\n              Kauffman\n              C.\n              Saccente\n              M.\n              Haas\n              D.\n              Pankey\n              G.\n              Lancaster\n              D.\n              Holloway\n              M.\n              Cloud\n              G.\n              Dismukes\n              W.\n          Cryptococcosis in non-HIV infected patients: a multicenter survey abstr. 128.\n          Thirty-fifth Infectious Disease Society of America\n          1997"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","unstructured":"Perfect J. R. 1990. Fluconazole therapy for experimental cryptococcosis and candidiasis in the rabbit. Rev. Infect. Dis. 12 (Suppl. 3):299\u2013302.","DOI":"10.1093\/clinids\/12.Supplement_3.S299"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.8.1910"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.3.429"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.28.6.751"},{"key":"e_1_3_2_14_2","first-page":"177","article-title":"Chronic cryptococcal meningitis: a new experimental model in rabbits.","volume":"101","author":"Perfect J. R.","year":"1980","unstructured":"Perfect J. R. Lang S. D. R. Durack D. T. Chronic cryptococcal meningitis: a new experimental model in rabbits. Am. J. Pathol. 101 1980 177 194","journal-title":"Am. J. Pathol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.29.4.579"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/33.1.73"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.10.1735"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503163321102"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203193261203"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.5.975-a"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201093260202"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1248\/cpb.45.321","article-title":"Optically active antifungal azoles. VII. Synthesis and antifungal activity of stereoisomers of 2-[(1R,2R)-2-(2,4-difluorophe-nyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-[4-(2,2,3,3-tetra-fluoropropoxy)phenyl]-3(2H,4H)-1,2,4-triazolone (TAK-187).","volume":"45","author":"Tasaka A.","year":"1997","unstructured":"Tasaka A. Kitazaki T. Tsuchimori N. Matsushita Y. Hayashi R. Okonogi K. Itoh K. Optically active antifungal azoles. VII. Synthesis and antifungal activity of stereoisomers of 2-[(1R,2R)-2-(2,4-difluorophe-nyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-[4-(2,2,3,3-tetra-fluoropropoxy)phenyl]-3(2H,4H)-1,2,4-triazolone (TAK-187). Chem. Pharm. Bull. 45 1997 321 326","journal-title":"Chem. Pharm. Bull."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707033370103"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92139-7"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/26.3.387"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.10.2630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.10.2630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:42:00Z","timestamp":1645458120000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.42.10.2630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["10.1128\/AAC.42.10.2630"],"URL":"https:\/\/doi.org\/10.1128\/aac.42.10.2630","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]},"assertion":[{"value":"1997-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}