{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T19:34:06Z","timestamp":1776108846630,"version":"3.50.1"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Beta-lactam resistance by\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            is becoming a significant threat to public health worldwide. However, data concerning antibiotic susceptibility patterns in China have not been published. In this study, a total of 79 clinical isolates and 244 nasopharyngeal isolates of\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            were recovered between June and November 1997 in Beijing. The agreement between the MICs (\u00b11 log\n            <jats:sub>2<\/jats:sub>\n            dilution) of penicillin and ceftriaxone obtained by the agar dilution and E-test methods for the 79 clinical strains was very good (97.5 and 93.7%, respectively). Of these 79 strains, 9 (11.4%) were intermediate and 2 (2.5%) were resistant to penicillin. Of the 244 nasopharyngeal strains, 32 (13.1%) were intermediate and 3 (1.2%) were resistant to penicillin. The total of 277 penicillin-susceptible clinical and nasopharyngeal isolates of\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            were 100% susceptible to amoxicillin-clavulanic acid, cefuroxime, ceftriaxone, and cefotaxime. In the 35 penicillin-intermediate and -resistant nasopharyngeal strains, elevated MICs of amoxicillin-clavulanic acid, cefuroxime, ceftriaxone, and cefotaxime were seen for \u22644 isolates. Of 244 nasopharyngeal isolates, the overall percentages of tetracycline, erythromycin, chloramphenicol, ofloxacin, and trimethoprim-sulfamethoxazole resistance were 87.6, 74.0, 47.8, 3.7 and 63.3, respectively. Vancomycin and rifampin resistance were not detected. These findings demonstrate that the rate of penicillin-resistant pneumococci is relatively low in China compared to those of other Asian countries. Resistance to non-beta-lactams was much higher than to beta-lactams. The E-test and agar dilution methods appeared to be comparable in identifying resistant strains.\n          <\/jats:p>","DOI":"10.1128\/aac.42.10.2633","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:29:31Z","timestamp":1539044971000},"page":"2633-2636","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Antibiotic Susceptibility Patterns of\n            <i>Streptococcus pneumoniae<\/i>\n            in China and Comparison of MICs by Agar Dilution and E-Test Methods"],"prefix":"10.1128","volume":"42","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Clinical Laboratories, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, People\u2019s Republic of China,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Huebner","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->MRC\/SAIMR\/WITS Pneumococcal Diseases Research Unit, South African Institute for Medical Research, Johannesburg 2000, South Africa2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjun","family":"Chen","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Clinical Laboratories, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, People\u2019s Republic of China,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Klugman","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->MRC\/SAIMR\/WITS Pneumococcal Diseases Research Unit, South African Institute for Medical Research, Johannesburg 2000, South Africa2"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02013089"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.1.77"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510470035031"},{"key":"e_1_3_2_5_2","unstructured":"Doern\n              G. V.\n          Susceptibility tests of fastidious bacteria\n          Manual of clinical microbiology\n          6th ed.\n              Murray\n              P. R.\n              Baron\n              E. J.\n              Pfaller\n              M. A.\n              Tenover\n              F. C.\n              Yolken\n              R. H.\n          1995\n          1342\n          1349\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.5.1208"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.1.49"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199206000-00002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199408113310607"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.8.1630"},{"key":"e_1_3_2_11_2","first-page":"364","article-title":"Invasive Streptococcus pneumoniae infection associated with rapidly fatal outcome in Taiwan.","volume":"95","author":"Hsueh P. R.","year":"1996","unstructured":"Hsueh P. R. Wu J. J. Hsiue T. R. Invasive Streptococcus pneumoniae infection associated with rapidly fatal outcome in Taiwan. J. Formos. Med. Assoc. 95 1996 364 371","journal-title":"J. Formos. Med. Assoc."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.1.119"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(92)90093-9"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.1996.2.401"},{"key":"e_1_3_2_15_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Approved standard M7-A4. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically\n          4th ed.\n          1997\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.10.2171"},{"key":"e_1_3_2_17_2","unstructured":"Song\n              J. H.\n              Yang\n              J. W.\n              Jin\n              J. H.\n              Peck\n              K. R.\n              Kim\n              S.\n              Lee\n              N. Y.\n              Jacobs\n              M. R.\n              Appelbaum\n              P. C.\n          Molecular epidemiology of multidrug-resistant pneumococci in Korea abstr. C-170\n          Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1997\n          75\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.6.1273"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/514526"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.10.2633","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.10.2633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:39:30Z","timestamp":1645457970000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.42.10.2633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["10.1128\/AAC.42.10.2633"],"URL":"https:\/\/doi.org\/10.1128\/aac.42.10.2633","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]},"assertion":[{"value":"1998-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}