{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:09:27Z","timestamp":1761156567292},"reference-count":25,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Protegrins, potent antimicrobial peptides found in porcine leukocytes, have activity against the sexually transmitted pathogens\n            <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n            ,\n            <jats:italic>Chlamydia trachomatis<\/jats:italic>\n            , and human immunodeficiency virus type 1. We tested synthetic protegrin 1 (PG-1) for activity against nine isolates of\n            <jats:italic>Haemophilus ducreyi<\/jats:italic>\n            , the etiologic agent of chancroid. The test organisms included CIP 542 (the type strain), 35000HP (a human-passaged variant of 35000), 35000HP-RSM2 (an isogenic\n            <jats:sc>d<\/jats:sc>\n            -\n            <jats:italic>glycero<\/jats:italic>\n            -\n            <jats:sc>d<\/jats:sc>\n            -\n            <jats:italic>manno<\/jats:italic>\n            -heptosyltransferase mutant of 35000HP), and six clinical isolates. The isolates were epidemiologically unrelated, represented three\n            <jats:italic>Hin<\/jats:italic>\n            dIII ribotypes, and had varying antimicrobial resistance patterns. In bactericidal assays, five isolates were rapidly killed by synthetic PG-1. In radial diffusion assays, all nine isolates were exquisitely sensitive to PG-1. These data highlight the potential of protegrins for development as topical agents to prevent many sexually transmitted diseases, including chancroid.\n          <\/jats:p>","DOI":"10.1128\/aac.42.10.2690","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:29:31Z","timestamp":1539044971000},"page":"2690-2693","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["<i>Haemophilus ducreyi<\/i>\n            Is Susceptible to Protegrin"],"prefix":"10.1128","volume":"42","author":[{"given":"Kate","family":"Fortney","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Departments of Medicine,1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"Totten","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Medicine, University of Washington, Seattle, Washington 981042; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert I.","family":"Lehrer","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Department of Medicine3 and"},{"name":"<!--label omitted: 4-->Molecular Biology Institute,4 University of California, Los Angeles, Los Angeles, California 90095"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley M.","family":"Spinola","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments of Medicine,1"},{"name":"<!--label omitted: 5-->Microbiology and Immunology,5 and"},{"name":"<!--label omitted: 6-->Pathology and Laboratory Medicine,6 School of Medicine, Indiana University, Indianapolis, Indiana 46202;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.2.451"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.7.1303"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.16.5062-5071.1997"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1996.0352h.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-25-4-351"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.7.1552"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)80175-T"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(91)90021-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.2.564-570.1996"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.2.2.137"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.4.1240-1245.1996"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.65.2.636-639.1997"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.9.1949-1954.1991"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.18.5316-5321.1995"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/173.2.394"},{"key":"e_1_3_2_17_2","first-page":"169","article-title":"Designer assays for antimicrobial peptides. Disputing the \u201cone-size-fits-all\u201d theory.","volume":"78","author":"Steinberg D. A.","year":"1997","unstructured":"Steinberg D. A. Lehrer R. I. Designer assays for antimicrobial peptides. Disputing the \u201cone-size-fits-all\u201d theory. Methods Mol. Biol. 78 1997 169 186","journal-title":"Methods Mol. Biol."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.43.853"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-119-12-199312150-00005"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.32.8.2019-2023.1994"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.8.3.357"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-199219020-00001"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.3.709-713.1996"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.64.11.4863-4866.1996"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00633-K"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)00493-5"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.10.2690","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.10.2690","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T15:39:37Z","timestamp":1645457977000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.42.10.2690"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["10.1128\/AAC.42.10.2690"],"URL":"https:\/\/doi.org\/10.1128\/aac.42.10.2690","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]},"assertion":[{"value":"1998-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-10-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}