{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:57:44Z","timestamp":1761490664213},"reference-count":19,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A recently developed diaminotriazine derivative [\n            <jats:italic>O<\/jats:italic>\n            ,\n            <jats:italic>O<\/jats:italic>\n            \u2032-bis(1,2-dihydro-2,2-tetramethylene-4,6-diamino-\n            <jats:italic>S<\/jats:italic>\n            -triazin-1-yl)-1,6-hexanediol dihydrochloride; T-46; SIPI 1029] was examined for activity against African trypanosomes in in vitro and in vivo model systems. In vitro, SIPI 1029 was 50% inhibitory for growth of bloodstream trypomastigotes of four strains of\n            <jats:italic>Trypanosoma brucei brucei<\/jats:italic>\n            and\n            <jats:italic>Trypanosoma brucei rhodesiense<\/jats:italic>\n            at 0.15 to 2.15 nM (50% inhibitory concentrations). In in vivo mouse laboratory models of\n            <jats:italic>T.\u2009b. rhodesiense<\/jats:italic>\n            clinical isolate infections, SIPI 1029 was curative for 12 of 13 isolates at \u226410 mg\/kg of body weight\/day for 3 days. In eight infections, a single dose was \u226560% curative, and in six of these, a dose of \u22645 mg\/kg was sufficient for \u226560% cure rates. A number of these isolates were resistant to the standard trypanocide melarsoprol (Arsobal) and\/or the diamidines diminazene aceturate (Berenil) and pentamidine. SIPI 1029 was also curative in combination with\n            <jats:sc>dl<\/jats:sc>\n            -\u03b1-difluoromethylornithine (Ornidyl) in a\n            <jats:italic>T.\u2009b. brucei<\/jats:italic>\n            central nervous system model infection. Some evidence of toxicity was found in dosage regimens of 10 mg\/kg\/day for 2 or 3 days in which deaths were observed in 6 of 65 animals given this dosage regimen. The activity of SIPI 1029 in this study indicates that this class of compounds (diaminotriazines) should be explored as leads for new human and veterinary trypanocides.\n          <\/jats:p>","DOI":"10.1128\/aac.42.10.2718","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:29:31Z","timestamp":1539044971000},"page":"2718-2721","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":18,"title":["Antitrypanosomal Activity of a New Triazine Derivative, SIPI 1029, In Vitro and in Model Infections"],"prefix":"10.1128","volume":"42","author":[{"given":"Cyrus J.","family":"Bacchi","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Haskins Laboratories1and"},{"name":"<!--label omitted: 2-->Biology Department,2 Pace University, New York, New York 10038, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Vargas","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Haskins Laboratories1and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna","family":"Rattendi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Haskins Laboratories1and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burt","family":"Goldberg","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Haskins Laboratories1and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weicheng","family":"Zhou","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Shanghai Institute of Pharmaceutical Industry, Shanghai, 200437, China3"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.9.1406"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.6.1448"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90524-Z"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.6.1183"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.3.563"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2370685"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.6.1442"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.11.4.9068614"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2307\/3282883"},{"key":"e_1_3_2_11_2","first-page":"147","article-title":"Relapsed parasitemia following chemotherapy of chronic Trypanosoma brucei infections in mice and its relationship to cerebral trypanosomes.","volume":"7","author":"Jennings F. W.","year":"1983","unstructured":"Jennings F. W. Gray A. R. Relapsed parasitemia following chemotherapy of chronic Trypanosoma brucei infections in mice and its relationship to cerebral trypanosomes. Contrib. Microbiol. Immunol. 7 1983 147 154","journal-title":"Contrib. Microbiol. Immunol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1980.11687360"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1982.11687588"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0001-706X(93)90089-T"},{"issue":"18","key":"e_1_3_2_15_2","first-page":"A1","article-title":"Deadly epidemic emerges in Sudan.","volume":"1997","author":"McKinley J. C.","year":"1997","unstructured":"McKinley J. C. Jr. Deadly epidemic emerges in Sudan. N. Y. Times 1997 18 July 1997 A1","journal-title":"N. Y. 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