{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:24:12Z","timestamp":1790663052472,"version":"4.1.0"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1998,2,1]],"date-time":"1998-02-01T00:00:00Z","timestamp":886291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The release of lipoteichoic acid (LTA) and teichoic acid (TA) from a\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            type 3 strain during exposure to ceftriaxone, meropenem, rifampin, rifabutin, quinupristin-dalfopristin, and trovafloxacin in tryptic soy broth was monitored by a newly developed enzyme-linked immunosorbent assay. At a concentration of 10 \u03bcg\/ml, a rapid and intense release of LTA and TA occurred during exposure to ceftriaxone (3,248 \u00b1 1,688 ng\/ml at 3 h and 3,827 \u00b1 2,133 ng\/ml at 12 h) and meropenem (2,464 \u00b1 1,081 ng\/ml at 3 h and 2,900 \u00b1 1,364 ng\/ml at 12 h). Three hours after exposure to rifampin, rifabutin, quinupristin-dalfopristin, and trovafloxacin, mean LTA and TA concentrations of less than 460 ng\/ml were observed (for each group,\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.01 versus the concentrations after exposure to ceftriaxone). After 12 h of treatment, the LTA and TA concentrations were 463 \u00b1 126 ng\/ml after exposure to rifampin, 669 \u00b1 303 ng\/ml after exposure to rifabutin, and 1,236 \u00b1 772 ng\/ml after exposure to quinupristin-dalfopristin (for each group,\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05 versus the concentrations after exposure to ceftriaxone) and 1,745 \u00b1 1,185 ng\/ml after exposure to trovafloxacin (\n            <jats:italic>P<\/jats:italic>\n            = 0.12 versus the concentration after exposure to ceftriaxone). At 10 \u03bcg\/ml, bactericidal antibacterial agents that do not primarily affect cell wall synthesis reduced the amount of LTA and TA released during their cidal action against\n            <jats:italic>S. pneumoniae<\/jats:italic>\n            in comparison with the amount released after exposure to \u03b2-lactams. Larger quantities of LTA and TA were released after treatment with low concentrations (1\u00d7 the MIC and 1\u00d7 the minimum bactericidal concentration) than after no treatment for all antibacterial agents except the rifamycins. This does not support the concept of using a low first antibiotic dose to prevent the release of proinflammatory cell wall components.\n          <\/jats:p>","DOI":"10.1128\/aac.42.2.277","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T16:18:54Z","timestamp":1585930734000},"page":"277-281","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":37,"title":["Differential Release of Lipoteichoic and Teichoic Acids from\n            <i>Streptococcus pneumoniae<\/i>\n            as a Result of Exposure to \u03b2-Lactam Antibiotics, Rifamycins, Trovafloxacin, and Quinupristin-Dalfopristin"],"prefix":"10.1128","volume":"42","author":[{"given":"K.","family":"Stuertz","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Departments ofNeurology,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments ofNeurology,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Eiffert","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Medical Microbiology,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Morphology,3 University of Go\u0308ttingen, Go\u0308ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ma\u0308der","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments ofNeurology,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Nau","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Departments ofNeurology,1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1432-1033.1992.tb17143.x","article-title":"The structure of pneumococcal lipoteichoic acid.","volume":"207","author":"Behr T.","year":"1992","unstructured":"Behr T. 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Biochem."},{"key":"e_1_3_2_3_2","unstructured":"Dever\n              L.\n              Tarasi\n              A.\n              Tomasz\n              A.\n          Bactericidal activity of RP59500 against Streptococcus pneumoniae in the rabbit model of experimental meningitis.\n          The 3rd International Conference on the Macrolides Azalides and Streptogramins\n          1996"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.6.1336"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.7.2715-2721.1994"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/infdis\/165.6.1033","article-title":"\u03b2-Lactam antibiotic-induced release of free endotoxin: in vitro comparison of penicillin-binding protein (PBP) 2-specific imipenem and PBP 3-specific ceftazidime.","volume":"165","author":"Jackson J. J.","year":"1992","unstructured":"Jackson J. J. 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