{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:55:55Z","timestamp":1775246155667,"version":"3.50.1"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Few chemotherapeutic agents are available for the medical management of hydatid disease caused by the parasite\n                    <jats:italic>Echinococcus granulosus<\/jats:italic>\n                    . In order to test the potential of oxfendazole for the treatment of infection with this parasite, nine infected goats and four sheep were given oxfendazole twice weekly at a dose of 30 mg\/kg of body weight for 4 weeks and monitored by ultrasound for an additional 4 weeks. Efficacy was finally evaluated by postmortem examination, including determination of protoscolex viability and cyst wall histology. In treated animals, protoscolices were dead or absent in 97% of cysts from oxfendazole-treated animals compared to 28% of cysts from untreated control animals. On postmortem examination, 53% of cysts from treated animals were found to be grossly degenerate. A sample of those cysts that appeared potentially viable all demonstrated evidence of severe damage to the cyst wall. By light microscopy, cysts showed severe disorganization of the adventitial layer with invasion of inflammatory cells and in some cases frank necrosis with no apparent adventitial layer. The follow-up period for assessment of the drug\u2019s ability to cause complete degeneration and resorption of cysts was relatively short. This study, however, indicates that oxfendazole is at least as effective as and is easier to administer than albendazole for the treatment of hydatid disease.\n                  <\/jats:p>","DOI":"10.1128\/aac.42.3.601","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T20:30:35Z","timestamp":1539030635000},"page":"601-605","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":27,"title":["Oxfendazole Treatment for Cystic Hydatid Disease in Naturally Infected Animals"],"prefix":"10.1128","volume":"42","author":[{"given":"Ronald E.","family":"Blanton","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of Geographic Medicine, Department of Medicine, Case Western Reserve University and University Hospitals, Cleveland, Ohio 441061;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M.","family":"Wachira","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->African Medical and Research Foundation,2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eberhard E.","family":"Zeyhle","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->African Medical and Research Foundation,2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest M.","family":"Njoroge","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Nairobi University School of Veterinary Medicine,3and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Japheth K.","family":"Magambo","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Jomo Kenyatta University of Agriculture and Technology,4 Nairobi, Kenya; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Schantz","sequence":"additional","affiliation":[{"name":"<!--label omitted: 5-->Centers for Disease Control and Prevention, Atlanta, Georgia 303295"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Ammann R. Eckert J. Clinical diagnosis and treatment of echinococcosis in humans Echinococcosis and hydatid disease. Thompson R. C. A. Lymbery A. J. 1995 411 463 CAB International Oxford United Kingdom"},{"key":"e_1_3_2_3_2","first-page":"65","article-title":"Evaluation of a program to control hydatid disease in central Utah.","volume":"43","author":"Andersen F. L.","year":"1983","unstructured":"Andersen F. L. Crellin J. R. Nichols C. R. Schantz P. M. Evaluation of a program to control hydatid disease in central Utah. Great Basin Nat. 43 1983 65 72","journal-title":"Great Basin Nat."},{"key":"e_1_3_2_4_2","first-page":"433","article-title":"Cause of death in 339 Alaskan natives as determined by autopsy.","volume":"90","author":"Arthaud J. B.","year":"1970","unstructured":"Arthaud J. B. Cause of death in 339 Alaskan natives as determined by autopsy. Arch. Pathol. 90 1970 433 438","journal-title":"Arch. Pathol."},{"key":"e_1_3_2_5_2","first-page":"35","article-title":"The prevalence and distribution of hydatidosis in China.","volume":"3","author":"Chi P.","year":"1989","unstructured":"Chi P. Fan Y. Zhang Z. Zhang Y. Hasyet M. Liu W. Jia W. Ye F. Chen Y. Ming R. Sung Y. The prevalence and distribution of hydatidosis in China. Xinjiang Agric. Sci. 3 1989 35 38","journal-title":"Xinjiang Agric. Sci."},{"key":"e_1_3_2_6_2","unstructured":"Computer Associates International CA-Cricket Graph III 1.5.1 ed. 1993 Computer Associates International Inc. Islandia N.Y"},{"key":"e_1_3_2_7_2","first-page":"383","article-title":"Multicentre clinical trials of benzimidazolecarbamates in human echinococcosis.","volume":"64","author":"Davis A.","year":"1986","unstructured":"Davis A. Pawlowski Z. S. Dixon H. Multicentre clinical trials of benzimidazolecarbamates in human echinococcosis. Bull. W. H. O. 64 1986 383 388","journal-title":"Bull. W. H. O."},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0034-5288(18)32902-3","article-title":"The effect of oxfendazole on Echinococcus granulosus and Taenia hydatigena infections in dogs.","volume":"26","author":"Gemmell M. A.","year":"1979","unstructured":"Gemmell M. A. Johnstone P. D. Oudemans G. The effect of oxfendazole on Echinococcus granulosus and Taenia hydatigena infections in dogs. Res. Vet. Sci. 26 1979 389 390","journal-title":"Res. Vet. Sci."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1017\/S0031182000065483","article-title":"Population dynamics in echinococcosis and cysticercosis: biological parameters of Echinococcus granulosus in dogs and sheep.","volume":"92","author":"Gemmell M. A.","year":"1986","unstructured":"Gemmell M. A. Lawson J. R. Roberts M. G. Population dynamics in echinococcosis and cysticercosis: biological parameters of Echinococcus granulosus in dogs and sheep. Parasitology 92 1986 599 620","journal-title":"Parasitology"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00930490","article-title":"Effect of mebendazole against Echinococcus granulosus and Taenia hydatigena cysts in naturally infected sheep and relevance to larval tapeworm infections in man.","volume":"64","author":"Gemmell M. A.","year":"1981","unstructured":"Gemmell M. A. Parmeta S. N. Sutton R. J. Khan N. Effect of mebendazole against Echinococcus granulosus and Taenia hydatigena cysts in naturally infected sheep and relevance to larval tapeworm infections in man. Z. Parasitenkd. 64 1981 135 147","journal-title":"Z. Parasitenkd."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.4269\/ajtmh.1996.54.391","article-title":"Effective, single-dose treatment of porcine cysticercosis with oxfendazole.","volume":"54","author":"Gonzales A. E.","year":"1996","unstructured":"Gonzales A. E. Garcia H. H. Gilman R. H. Gavidia C. M. Tsang V. C. W. Bernal T. Falcon N. Romero M. Lopez-Urbina M. T. Effective, single-dose treatment of porcine cysticercosis with oxfendazole. Am. J. Trop. Med. Hyg. 54 1996 391 394","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1017\/S0031182000059771","article-title":"Echinococcus granulosus: a comparison of free amino acid concentration in hydatid fluid from primary and secondary cysts and host plasma.","volume":"98","author":"Hurd H.","year":"1989","unstructured":"Hurd H. Echinococcus granulosus: a comparison of free amino acid concentration in hydatid fluid from primary and secondary cysts and host plasma. Parasitology 98 1989 135 143","journal-title":"Parasitology"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2307\/3278534","article-title":"Helminth control in grazing sheep: periodic treatment with levamisole, morantel, cambendazole and mebendazole.","volume":"60","author":"Kates K. C.","year":"1974","unstructured":"Kates K. C. Colglazier M. L. Enzie F. D. Lindahl I. L. Samuelson G. Helminth control in grazing sheep: periodic treatment with levamisole, morantel, cambendazole and mebendazole. J. Parasitol. 60 1974 989 995","journal-title":"J. Parasitol."},{"key":"e_1_3_2_14_2","unstructured":"Liu F.-J. Che X.-H. Chang Q. Prevalence of hydatid cysts in livestock in the Xinjiang Uygur Autonomous Region PRC Compendium on cystic echinococcosis with special reference to the Xinjiang Uygur Autonomous Region The People\u2019s Republic of China Anderson F. L. Chai J.-J. Liu F.-J. 1993 177 189 Brigham Young University Print Services Provo Utah"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90839-7"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2460\/ajvr.1980.41.07.1126","article-title":"Pharmacokinetics of albendazole in sheep.","volume":"41","author":"Marriner S. E.","year":"1980","unstructured":"Marriner S. E. Bogan J. A. Pharmacokinetics of albendazole in sheep. Am. J. Vet. Res. 41 1980 1126 1129","journal-title":"Am. J. Vet. Res."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.2460\/ajvr.1981.42.07.1143","article-title":"Pharmacokinetics of oxfendazole in sheep.","volume":"42","author":"Marriner S. E.","year":"1981","unstructured":"Marriner S. E. Bogan J. A. Pharmacokinetics of oxfendazole in sheep. Am. J. Vet. Res. 42 1981 1143 1145","journal-title":"Am. J. Vet. Res."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.2042-3306.1985.tb02043.x","article-title":"Plasma concentrations of fenbendazole and oxfendazole in the horse.","volume":"17","author":"Marriner S. E.","year":"1985","unstructured":"Marriner S. E. Bogan J. A. Plasma concentrations of fenbendazole and oxfendazole in the horse. Equine Vet. J. 17 1985 58 61","journal-title":"Equine Vet. J."},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0020-7519(96)00124-5","article-title":"The use of ultrasound to study the prevalence of hydatid cysts in the right lung and liver of sheep and goats in Turkana.","volume":"26","author":"Maxson A. D.","year":"1996","unstructured":"Maxson A. D. Wachira T. M. Zeyhle E. E. Fine A. Mwangi T. W. Smith G. The use of ultrasound to study the prevalence of hydatid cysts in the right lung and liver of sheep and goats in Turkana. Int. J. Parasitol. 26 1996 1335 1338","journal-title":"Int. J. Parasitol."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/gut.28.1.75","article-title":"Penetration of albendazole sulphoxide into hydatid cysts.","volume":"28","author":"Morris D. L.","year":"1987","unstructured":"Morris D. L. Chinnery J. B. Georgiou G. Stamanakis G. Golematis B. Penetration of albendazole sulphoxide into hydatid cysts. Gut 28 1987 75 80","journal-title":"Gut"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/thx.40.6.453","article-title":"Albendazole treatment of pulmonary hydatid cysts in naturally infected sheep: a study with relevance to the treatment of hydatid cysts in man.","volume":"40","author":"Morris D. L.","year":"1985","unstructured":"Morris D. L. Clarkson M. J. Stallbaumer M. F. Pritchard J. Jones R. S. Chinnery J. B. Albendazole treatment of pulmonary hydatid cysts in naturally infected sheep: a study with relevance to the treatment of hydatid cysts in man. Thorax 40 1985 453 458","journal-title":"Thorax"},{"key":"e_1_3_2_22_2","unstructured":"Schantz P. M. Chai J. Craig P. S. Eckert J. Jenkins D. J. Macpherson C. N. L. Thakur A. Epidemiology and control of hydatid disease Echinococcosis and hydatid disease. Thompson R. C. A. Lymbery A. J. 1995 233 331 CAB International Oxford United Kingdom"},{"key":"e_1_3_2_23_2","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0035-9203(80)90157-1","article-title":"Procedures for testing the viability of human hydatid cysts following surgical removal especially after chemotherapy.","volume":"74","author":"Smyth J. D.","year":"1980","unstructured":"Smyth J. D. Barrett N. J. Procedures for testing the viability of human hydatid cysts following surgical removal especially after chemotherapy. Trans. R. Soc. Trop. Med. Hyg. 74 1980 849 852","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"e_1_3_2_24_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4269\/ajtmh.1993.48.473","article-title":"Molecular examination of the sympatry and distribution of sheep and camel strains of Echinococcus granulosus in Kenya.","volume":"48","author":"Wachira T. M. H.","year":"1993","unstructured":"Wachira T. M. H. Bowles J. Zeyhle E. McManus D. P. Molecular examination of the sympatry and distribution of sheep and camel strains of Echinococcus granulosus in Kenya. Am. J. Trop. Med. Hyg. 48 1993 473 479","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_3_2_25_2","first-page":"231","article-title":"Guidelines for treatment of cystic and alveolar echinococcosis in humans.","volume":"74","author":"WHO Informal Working Group","year":"1996","unstructured":"WHO Informal Working Group Guidelines for treatment of cystic and alveolar echinococcosis in humans. Bull. W. H. O. 74 1996 231 242","journal-title":"Bull. W. H. O."},{"key":"e_1_3_2_26_2","unstructured":"Zeyhle E. E. Personal communication."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.3.601","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.3.601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:01:24Z","timestamp":1775242884000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.42.3.601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["10.1128\/AAC.42.3.601"],"URL":"https:\/\/doi.org\/10.1128\/aac.42.3.601","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3]]},"assertion":[{"value":"1997-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1997-12-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}