{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:38:27Z","timestamp":1788345507667,"version":"build-2803163510"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The susceptibilities of three bovine and two human\n            <jats:italic>Babesia divergens<\/jats:italic>\n            isolates to antimicrobial agents were evaluated in vitro by a tritiated hypoxanthine incorporation assay. The MICs at which 50% of isolates are inhibited (MIC\n            <jats:sub>50<\/jats:sub>\n            s) for mefloquine (chlorhydrate), chloroquine (sulfate), quinine (chlorhydrate), clindamycin (phosphate), pentamidine (isethionate), phenamidine (isethionate) plus oxomemazine (chlorhydrate), lincomycin (chlorhydrate monohydrate), and imidocarb (dipropionate) were determined. Except for imidocarb, the MIC\n            <jats:sub>50<\/jats:sub>\n            s observed for the different isolates were close. Imidocarb and the combination of phenamidine plus oxomemazine exhibited the highest in vitro activity, while antimalarial agents such as mefloquine, choroquine, and quinine were inactive. Other drugs had intermediate activities. The data support further in vitro evaluation of antimicrobial agents active against\n            <jats:italic>B. divergens<\/jats:italic>\n            for the improvement of therapeutic strategies.\n          <\/jats:p>","DOI":"10.1128\/aac.42.4.818","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:31:10Z","timestamp":1539045070000},"page":"818-820","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["In Vitro Evaluation of Drug Susceptibilities of\n            <i>Babesia divergens<\/i>\n            Isolates"],"prefix":"10.1128","volume":"42","author":[{"given":"Philippe","family":"Brasseur","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Parasitologie, Centre Hospitalier Universitaire, Ho\u0302pital Charles Nicolle, 76031 Rouen,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lecoublet","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Parasitologie, Centre Hospitalier Universitaire, Ho\u0302pital Charles Nicolle, 76031 Rouen,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Kapel","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Laboratoire de Parasitologie, Faculte\u0301 de Sciences Pharmaceutiques et Biologiques, 75006 Paris,2 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loic","family":"Favennec","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Laboratoire de Parasitologie, Centre Hospitalier Universitaire, Ho\u0302pital Charles Nicolle, 76031 Rouen,1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean J.","family":"Ballet","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->Laboratoire d\u2019Immunologie et Immunopathologie, Centre Hospitalier Universitaire, Ho\u0302pital Cle\u0301menceau, 14033 Caen,3France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","first-page":"3674","article-title":"Human piroplasmosis. 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P.\n          1992\n          17\n          Academic Press Inc.\n          New York N.Y","DOI":"10.1016\/B978-0-12-426015-3.50006-6"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.4.818","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.4.818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:44:14Z","timestamp":1645479854000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.42.4.818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["10.1128\/AAC.42.4.818"],"URL":"https:\/\/doi.org\/10.1128\/aac.42.4.818","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4]]},"assertion":[{"value":"1997-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-01-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}