{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:28:49Z","timestamp":1787016529909,"version":"build-2736575974"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In vitro and in vivo antidermatophyte activities of NND-502, a new imidazole antimycotic agent, were compared with those of two existing antifungal agents, lanoconazole and terbinafine. NND-502 exhibited strong in vitro antifungal activity against\n                    <jats:italic>Trichophyton<\/jats:italic>\n                    spp.; its MIC was 1 to 4 times lower than that of lanoconazole or terbinafine. In an in vivo study with a guinea pig model of tinea pedis, 7-day topical treatment with a 0.5% solution of NND-502 (dissolved in polyethylene glycol 400) was more effective than that with a 0.5% solution of either lanoconazole or terbinafine for eradicating fungi from the infected feet. When the duration of treatment was shortened to 3 days, a topical 1% solution of NND-502 achieved a complete mycological cure, while topical 1% solutions of lanoconazole and terbinafine did not.\n                  <\/jats:p>","DOI":"10.1128\/aac.42.4.967","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T20:31:10Z","timestamp":1539030670000},"page":"967-970","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["In Vitro and In Vivo Antidermatophyte Activities of NND-502, a Novel Optically Active Imidazole Antimycotic Agent"],"prefix":"10.1128","volume":"42","author":[{"given":"Yoshimi","family":"Niwano","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Research Center, Nihon Nohyaku Co., Ltd., Kawachinagano, Osaka 586,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kuzuhara","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Research Center, Nihon Nohyaku Co., Ltd., Kawachinagano, Osaka 586,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kodama","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Research Center, Nihon Nohyaku Co., Ltd., Kawachinagano, Osaka 586,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Yoshida","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Research Center, Nihon Nohyaku Co., Ltd., Kawachinagano, Osaka 586,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneo","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Research Center, Nihon Nohyaku Co., Ltd., Kawachinagano, Osaka 586,1 and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyo","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Teikyo University Institute of Medical Mycology, 359 Otsuka, Hachioji, Tokyo 192-03,2 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3314\/jjmm.33.541","article-title":"Butenafine, a new benzylamine derivative: in vitro effect on arthrospores of T. mentagrophytes and therapeutic efficacy on experimental tinea pedis in guinea pigs.","volume":"33","author":"Arika T.","year":"1992","unstructured":"Arika T. Yokoo M. Yamaguchi H. Butenafine, a new benzylamine derivative: in vitro effect on arthrospores of T. mentagrophytes and therapeutic efficacy on experimental tinea pedis in guinea pigs. Jpn. J. Med. Mycol. 33 1992 541 547","journal-title":"Jpn. J. Med. Mycol."},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.11.2254"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","unstructured":"Cordero C. I. de la Rosa Z. Espinosa R. F. Rojas and N. Zaias. 1992. Short-term therapy of tinea cruris\/corporis with topical terbinafine. J. Dermotol. Treatment 3 (Suppl. 1) : 23\u201324.","DOI":"10.3109\/09546639209088697"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1136\/bmj.307.6905.645","article-title":"Comparison of terbinafine and clotrimazole in treating tinea pedis.","volume":"307","author":"Evans E. G. V.","year":"1993","unstructured":"Evans E. G. V. Dodman B. Williamson D. M. Brown G. J. Bowen R. G. 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Dermatologica 66 (Suppl. 1) : 20\u201333.","DOI":"10.1159\/000249910"},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/02681218780000541","article-title":"Experimental tinea pedis by non-abrasive inoculation of Trichophyton mentagrophytes arthrospores on the plantar part of guinea pig foot.","volume":"25","author":"Fujita S.","year":"1987","unstructured":"Fujita S. Matsuyama T. Experimental tinea pedis by non-abrasive inoculation of Trichophyton mentagrophytes arthrospores on the plantar part of guinea pig foot. J. Med. Vet. Mycol. 25 1987 203 213","journal-title":"J. Med. Vet. Mycol."},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3314\/jjmm1960.29.163","article-title":"Experimental tinea pedis in guinea pig feet-scanning electron microscopic and histological study of the infection.","volume":"29","author":"Fujita S.","year":"1988","unstructured":"Fujita S. Matsuyama T. Sato Y. Experimental tinea pedis in guinea pig feet-scanning electron microscopic and histological study of the infection. Jpn. J. Med. Mycol. 29 1988 163 168","journal-title":"Jpn. J. Med. Mycol."},{"key":"e_1_3_1_10_2","first-page":"593","article-title":"Clinical evaluation of terconazole. European experience.","volume":"34","author":"Hirsch H. A.","year":"1989","unstructured":"Hirsch H. A. Clinical evaluation of terconazole. European experience. J. Reprod. Med. 34 1989 593 596","journal-title":"J. Reprod. Med."},{"key":"e_1_3_1_11_2","unstructured":"Kodama H. Y. Niwano K. Kanai and M. Yoshida. April 1997. Japanese patent (Jpn Koukai Tokkyo Kouhou) H9-100279."},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1439-0507.1986.tb03256.x","article-title":"Treatment of dermatomycoses with topical fenticonazole and econazole.","volume":"29","author":"Kokoschka E. M.","year":"1986","unstructured":"Kokoschka E. M. Niebauer G. Mounari M. Monici Preti P. 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Dermatol."},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.10.2353"},{"key":"e_1_3_1_16_2","first-page":"847","article-title":"Antifungal activity of a new agent latoconazole in two tinea models.","volume":"41","author":"Ohmi T.","year":"1991","unstructured":"Ohmi T. Konaka S. Uchida M. Yamaguchi H. Antifungal activity of a new agent latoconazole in two tinea models. Arzneim.-Forsch.\/Drug Res. 41 1991 847 851","journal-title":"Arzneim.-Forsch.\/Drug Res."},{"key":"e_1_3_1_17_2","first-page":"345","article-title":"Therapeutic efficacy of latoconazole in formulations of clinical use on experimental dermatophytosis in guinea pigs.","volume":"42","author":"Oka H.","year":"1992","unstructured":"Oka H. Niwano Y. Ohmi T. Tanaka T. Uchida M. Yamaguchi H. Therapeutic efficacy of latoconazole in formulations of clinical use on experimental dermatophytosis in guinea pigs. 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