{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T02:11:31Z","timestamp":1770516691508,"version":"3.49.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Eighteen isolates of\n            <jats:italic>Blastomyces dermatitidis<\/jats:italic>\n            were evaluated for their in vitro susceptibilities to ketoconazole, itraconazole, and fluconazole. The MIC ranges were 0.1 to 0.4 \u03bcg\/ml for ketoconazole, \u22640.018 to 0.07 \u03bcg\/ml for itraconazole, and 2.5 to 4.0 \u03bcg\/ml for fluconazole. The ranges for the minimal lethal concentrations were 0.2 to 0.8 \u03bcg\/ml for ketoconazole, \u22640.018 to 0.07 \u03bcg\/ml for itraconazole, and 10 to 40 \u03bcg\/ml for fluconazole. Itraconazole was the most active agent against\n            <jats:italic>B. dermatitidis<\/jats:italic>\n            in vitro, while fluconazole was the least active. These results correlate with the clinical efficacies noted to date with doses of these agents used to treat blastomycosis.\n          <\/jats:p>","DOI":"10.1128\/aac.42.4.978","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:31:10Z","timestamp":1539045070000},"page":"978-980","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Susceptibilities of Clinical and Laboratory Isolates of\n            <i>Blastomyces dermatitidis<\/i>\n            to Ketoconazole, Itraconazole, and Fluconazole"],"prefix":"10.1128","volume":"42","author":[{"given":"Stanley W.","family":"Chapman","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases1 and"},{"name":"<!--label omitted: 2-->Department of Microbiology,2 School of Medicine, and Department of Clinical Pharmacy Practice,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. David","family":"Rogers","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Department of Microbiology,2 School of Medicine, and Department of Clinical Pharmacy Practice,"},{"name":"<!--label omitted: 3-->School of Pharmacy,3 University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"<!--label omitted: 4-->Department of Pathology, Fungus Testing Laboratory, School of Medicine, University of Texas Health Science Center, San Antonio, Texas 78284-77504"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna C.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Division of Infectious Diseases1 and"},{"name":"<!--label omitted: 2-->Department of Microbiology,2 School of Medicine, and Department of Clinical Pharmacy Practice,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","unstructured":"Bradsher R. W. 1996. Histoplasmosis and blastomycosis. Clin. Infect. Dis. 22 (Suppl. 2) : S102\u2013S111.","DOI":"10.1093\/clinids\/22.Supplement_2.S102"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"872","DOI":"10.7326\/0003-4819-103-6-872","article-title":"Ketoconazole therapy for endemic blastomycosis.","volume":"103","author":"Bradsher R. W.","year":"1985","unstructured":"Bradsher R. W. Rice D. C. Abernathy R. S. Ketoconazole therapy for endemic blastomycosis. Ann. Intern. Med. 103 1985 872 879","journal-title":"Ann. Intern. Med."},{"key":"e_1_3_1_4_2","unstructured":"Chapman\n              S. W.\n          Blastomyces dermatitidis\n          Principles and practice of infectious diseases\n          4th ed.\n              Mandell\n              G. E.\n              Bennet\n              J. E.\n              Dolin\n              R.\n          1995\n          2353\n          2365\n          Churchill and Livingstone Inc.\n          New York N.Y"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0002-9343(92)90575-V","article-title":"Itraconazole therapy for blastomycosis and histoplasmosis.","volume":"93","author":"Dismukes W. E.","year":"1992","unstructured":"Dismukes W. E. Bradsher R. W. Cloud G. C. Kauffman C. A. Chapman S. W. George R. B. Stevens D. A. Girard W. M. Saag M. S. Bowles-Patton C. Itraconazole therapy for blastomycosis and histoplasmosis. Am. J. Med. 93 1992 489 497","journal-title":"Am. J. 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Resnick A. Rose H. D. Medium for susceptibility testing and yeast phase conversion of Blastomyces dermatitidis. Mycopathologia 95 1986 25 28","journal-title":"Mycopathologia"},{"key":"e_1_3_1_10_2","unstructured":"McGinnis\n              M. R.\n              Rinaldi\n              M. G.\n          Antifungal drugs: mechanisms of action drug resistance susceptibility testing and assays of activity in biological fluids\n          Antibiotics in laboratory medicine\n          4th ed.\n              Lorian\n              V.\n          1986\n          176\n          211\n          The Williams & Wilkins Co.\n          Baltimore Md"},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1093\/clinids\/22.5.838","article-title":"High-dose fluconazole therapy for cryptococcal meningitis in patients with AIDS.","volume":"22","author":"Menicheetti F.","year":"1996","unstructured":"Menicheetti F. Fiorio F. Tosti A. Gatti G. Pasticci M. B. Miletich F. Marroni M. 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Approved standard M27-A.\n          1997\n          National Committee for Clinical Laboratory Standards\n          Wayne Pa"},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"861","DOI":"10.7326\/0003-4819-103-6-861","article-title":"Treatment of blastomycosis and histoplasmosis with ketoconazole: results of a prospective randomized trial.","volume":"103","author":"National Institute of Allergy and Infectious Diseases Mycosis Study Group","year":"1985","unstructured":"National Institute of Allergy and Infectious Diseases Mycosis Study Group Treatment of blastomycosis and histoplasmosis with ketoconazole: results of a prospective randomized trial. Ann. Intern. Med. 103 1985 861 872","journal-title":"Ann. Intern. Med."},{"key":"e_1_3_1_14_2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/clinids\/20.2.267","article-title":"Treatment of blastomycosis with fluconazole: a pilot study.","volume":"20","author":"Pappas P. 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