{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:26:25Z","timestamp":1762867585752},"reference-count":18,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The comparative in vitro activity of the ketolide HMR 3647 (RU 66647) and those of structurally related macrolide-lincosamide-streptogramin compounds (erythromycin, roxithromycin, azithromycin, clarithromycin, josamycin, lincomycin, pristinamycin, and quinupristin-dalfopristin) as well as those of benzylpenicillin, doxycycline, vancomycin, teicoplanin, levofloxacin, and rifapentine against 247 aerobic and facultative non-spore-forming gram-positive bacilli were determined by an agar dilution method. The ketolide was active against most organisms tested except\n            <jats:italic>Corynebacterium striatum<\/jats:italic>\n            , coryneform CDC group I2, and\n            <jats:italic>Oerskovia<\/jats:italic>\n            spp. The frequency of resistance to erythromycin and other macrolides as well as that to lincomycin was high. Pristinamycin and, to a lesser extent, quinupristin-dalfopristin were very active, but resistance to these agents was present in some strains of\n            <jats:italic>Rhodococcus equi<\/jats:italic>\n            ,\n            <jats:italic>Listeria<\/jats:italic>\n            spp.,\n            <jats:italic>C. striatum<\/jats:italic>\n            ,\n            <jats:italic>Erysipelothrix rhusiopathiae<\/jats:italic>\n            , and\n            <jats:italic>Oerskovia<\/jats:italic>\n            spp. HMR 3647 was very active against all erythromycin-sensitive and many erythromycin-nonsusceptible strains, especially\n            <jats:italic>Corynebacterium minutissimum<\/jats:italic>\n            ,\n            <jats:italic>Corynebacterium pseudodiphtheriticum<\/jats:italic>\n            ,\n            <jats:italic>Corynebacterium amycolatum<\/jats:italic>\n            , and\n            <jats:italic>Corynebacterium jeikeium<\/jats:italic>\n            . In vitro resistance to benzylpenicillin was common, but doxycycline, vancomycin, and teicoplanin were very active against most organisms tested except\n            <jats:italic>E. rhusiopathiae<\/jats:italic>\n            , against which glycopeptide antibiotics were not active. The in vitro activity of levofloxacin was remarkable, but resistance to this agent was common for\n            <jats:italic>C. amycolatum<\/jats:italic>\n            ,\n            <jats:italic>Corynebacterium urealyticum<\/jats:italic>\n            ,\n            <jats:italic>C. jeikeium<\/jats:italic>\n            , and\n            <jats:italic>Oerskovia<\/jats:italic>\n            spp. strains. Rifapentine was also very active in vitro against many organisms, but resistance to this agent was always present in\n            <jats:italic>E. rhusiopathiae<\/jats:italic>\n            and was very common in\n            <jats:italic>C. striatum<\/jats:italic>\n            and\n            <jats:italic>C. urealyticum.<\/jats:italic>\n          <\/jats:p>","DOI":"10.1128\/aac.42.5.1028","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:31:56Z","timestamp":1539045116000},"page":"1028-1033","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":46,"title":["In Vitro Susceptibilities of Aerobic and Facultative Non-Spore-Forming Gram-Positive Bacilli to HMR 3647 (RU 66647) and 14 Other Antimicrobials"],"prefix":"10.1128","volume":"42","author":[{"given":"Francisco","family":"Soriano","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Department of Medical Microbiology, Fundacio\u0301n Jime\u0301nez D\u0131\u0301az, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ferna\u0301ndez-Roblas","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medical Microbiology, Fundacio\u0301n Jime\u0301nez D\u0131\u0301az, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Calvo","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medical Microbiology, Fundacio\u0301n Jime\u0301nez D\u0131\u0301az, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Garci\u0301a-Calvo","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Department of Medical Microbiology, Fundacio\u0301n Jime\u0301nez D\u0131\u0301az, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","unstructured":"Barry A. L. P. C. Fuchs and S. D. Brown. 1997. Provisional interpretive criteria for quinupristin\/dalfopristin susceptibility tests. J. Antimicrob. Chemother. 39 (Suppl. A) : 87\u201392.","DOI":"10.1093\/jac\/39.suppl_1.87"},{"key":"e_1_3_2_3_2","unstructured":"Clarridge\n              J. E.\n              Spiegel\n              C. A. Corynebacterium and miscellaneous irregular gram-positive rods Erysipelothrix and Gardnerella Manual of clinical microbiology.\n              Murray\n              P. R.\n              Baron\n              E. J.\n              Pfaller\n              M. A.\n              Tenover\n              F. C.\n              Yolken\n              R. H.\n          1995\n          357\n          378\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.3.3.227"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.5.1033"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.5.1037"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.10.1.125"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.2.454"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.7.1273"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.6.1439"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"Moore L. S. B. Schneider and W. J. Holloway. 1997. Minimal inhibitory concentrations of quinupristin\/dalfopristin against clinical isolates of Corynebacterium jeikeium and Listeria monocytogenes . J. Antimicrob. Chemother. 39 (Suppl. A) : 67\u201368.","DOI":"10.1093\/jac\/39.suppl_1.67"},{"key":"e_1_3_2_12_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 4th ed. Approved standard. NCCLS document M7-A4.\n          1997\n          National Committee for Clinical Laboratory Standards\n          Villanova Pa"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01967505"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01691153"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.5.1196"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.39.1.208"},{"key":"e_1_3_2_17_2","unstructured":"Soriano\n              F.\n              Calvo\n              R.\n              Fern\u00e1ndez-Roblas\n              R.\n          In vitro activity of ketolide HMR 3647 (RU 66647) against gram-positive bacilli abstr. F-118\n          Program and abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1997\n          166\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","unstructured":"Statement 1996 CA-SFM. 1996. Zone sizes and MIC breakpoints for non-fastidious organisms. Clin. Microbiol. Infect. 2 (Suppl. 1) : 46\u201349.","DOI":"10.1111\/j.1469-0691.1996.tb00875.x"},{"key":"e_1_3_2_19_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0732-8893(93)90065-F","article-title":"Identification of clinical isolates of nondiphtherial Corynebacterium species and their antibiotic susceptibility patterns.","volume":"17","author":"Williams D. Y.","year":"1993","unstructured":"Williams D. Y. Selepak S. T. Gill V. J. Identification of clinical isolates of nondiphtherial Corynebacterium species and their antibiotic susceptibility patterns. Diagn. Microbiol. Infect. 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Dis."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.5.1028","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.5.1028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:05:24Z","timestamp":1645481124000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.42.5.1028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1128\/AAC.42.5.1028"],"URL":"https:\/\/doi.org\/10.1128\/aac.42.5.1028","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]},"assertion":[{"value":"1997-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-02-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}