{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:17:09Z","timestamp":1770815829692,"version":"3.50.1"},"reference-count":14,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A multicenter, randomized, controlled, investigator-blind study was performed to evaluate the safety and efficacy of oral cefdinir versus oral penicillin V for the treatment of pharyngitis due to group A beta-hemolytic streptococci (GABHS). Patients 13 years of age and older were randomized to receive either oral cefdinir (300 mg twice a day) for 5 days followed by placebo for 5 days or oral penicillin V (250 mg four times a day) for 10 days. Throat cultures were obtained, and signs and symptoms of pharyngitis were recorded at study admission and follow-up visits on study days 11 to 15, 16 to 20, and 25 to 31. Patients kept a diary to record medication intake and their assessment of throat pain at admission and at each day of study treatment. Five hundred fifty-eight patients were enrolled, of whom 432 (77.4%) were clinically and microbiologically evaluable. The GABHS eradication rates 5 to 10 days after completion of therapy were 193 of 218 (88.5%) in the cefdinir group and 176 of 214 (82.2%) in the penicillin group (\n            <jats:italic>P<\/jats:italic>\n            = 0.053). Clinical cure rates were 89.0 and 84.6%, respectively (\n            <jats:italic>P<\/jats:italic>\n            = 0.80). By the time of the long-term follow-up visit, 2 to 3 weeks after completion of treatment, 156 of 191 (81.7%) of the assessable cefdinir patients and 152 of 195 (77.9%) of the penicillin patients remained free of GABHS. Both treatments were well tolerated, with adverse reaction rates of 18.3% in the cefdinir study arm and 15.0% in the penicillin study arm (\n            <jats:italic>P<\/jats:italic>\n            = 0.278). Five-day treatment with cefdinir is safe and effective therapy for GABHS pharyngitis. Based on its twice-a-day dosage and shorter course of therapy, leading to potentially greater patient compliance, cefdinir may be considered for use in the treatment of pharyngitis caused by GABHS.\n          <\/jats:p>","DOI":"10.1128\/aac.42.5.1073","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:31:56Z","timestamp":1539045116000},"page":"1073-1075","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Five-Day Cefdinir Treatment for Streptococcal Pharyngitis"],"prefix":"10.1128","volume":"42","author":[{"given":"Kenneth J.","family":"Tack","sequence":"first","affiliation":[{"name":"<!--label omitted: 1-->Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel C.","family":"Henry","sequence":"additional","affiliation":[{"name":"<!--label omitted: 2-->Foothill Family Clinic,2 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Manford","family":"Gooch","sequence":"additional","affiliation":[{"name":"<!--label omitted: 3-->University of Utah School of Medicine and Medical Research Associates of Utah, Inc.,3 Salt Lake City, Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas N.","family":"Brink","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constance H.","family":"Keyserling","sequence":"additional","affiliation":[{"name":"<!--label omitted: 1-->Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan,1 and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"The Cefdinir Pharyngitis Study","family":"Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1542\/peds.96.4.758","article-title":"Treatment of acute streptococcal pharyngitis and prevention of rheumatic fever: a statement for health professionals.","volume":"96","author":"Dajani A.","year":"1995","unstructured":"Dajani A. Taubert K. Ferrieri P. Peter G. Shulman S. Treatment of acute streptococcal pharyngitis and prevention of rheumatic fever: a statement for health professionals. Pediatrics 96 1995 758 764","journal-title":"Pediatrics"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(87)80024-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0140-6736(80)91832-2","article-title":"Failure of penicillin to eradicate group A streptococci during an outbreak of pharyngitis.","author":"Gastanaduy A. S.","year":"1980","unstructured":"Gastanaduy A. S. Kaplan E. L. Huwe B. B. McKay C. Wannamaker L. W. Failure of penicillin to eradicate group A streptococci during an outbreak of pharyngitis. Lancet ii 1980 498 502","journal-title":"Lancet"},{"key":"e_1_3_2_5_2","unstructured":"Gooch\n              W. M.\n              III\n              Hedrick\n              J.\n              McCarty\n              J.\n              Nemeth\n              M. A.\n          Comparative safety and efficacy of cefdinir (CDR) and penicillin V-K (PEN) in the treatment of streptococcal pharyngitis\/tonsilitis abstr. LM46\n          Program and Abstracts of the 35th Interscience Conference on Antimicrobial Agents and Chemotherapy.\n          1995\n          335\n          American Society for Microbiology\n          Washington D.C"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/00365549509019013","article-title":"Is penicillin the appropriate treatment for recurrent tonsillopharyngitis? Results from a comparative randomized blind study of cefuroxime axetil and phenoxymethylpenicillin in children.","volume":"27","author":"Holm S.","year":"1995","unstructured":"Holm S. Henning C. Grahn E. Lomberg H. Staley H. Is penicillin the appropriate treatment for recurrent tonsillopharyngitis? Results from a comparative randomized blind study of cefuroxime axetil and phenoxymethylpenicillin in children. Scand. J. Infect. Dis. 27 1995 221 228","journal-title":"Scand. J. Infect. Dis."},{"key":"e_1_3_2_7_2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1099\/00222615-38-5-311","article-title":"A review of the correlation of T-agglutination patterns and M-protein typing and opacity factor production in the identification of group A streptococci.","volume":"38","author":"Johnson D. R.","year":"1993","unstructured":"Johnson D. R. Kaplan E. L. A review of the correlation of T-agglutination patterns and M-protein typing and opacity factor production in the identification of group A streptococci. J. Med. Microbiol. 38 1993 311 315","journal-title":"J. Med. Microbiol."},{"key":"e_1_3_2_8_2","unstructured":"National Committee for Clinical Laboratory Standards\n          Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A3.\n          1993\n          National Committee for Clinical Laboratory Standards\n          Villanova Pa"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.10.1795"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archpedi.1994.02170100051010","article-title":"Effective short-course treatment of acute group A beta-hemolytic streptococcal tonsillopharyngitis.","volume":"148","author":"Pichichero M. E.","year":"1994","unstructured":"Pichichero M. E. Gooch W. M. Rodriguez W. Blumer J. L. Aronoff S. C. Jacobs R. F. Musser J. M. Effective short-course treatment of acute group A beta-hemolytic streptococcal tonsillopharyngitis. Arch. Pediatr. Adolesc. Med. 148 1994 1053 1060","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/00006454-199104000-00002","article-title":"A comparison of cephalosporins and penicillins in the treatment of group A beta-hemolytic streptococcal pharyngitis: a meta-analysis supporting the concept of microbial copathogenicity.","volume":"10","author":"Pichichero M. E.","year":"1991","unstructured":"Pichichero M. E. Margolis P. A. A comparison of cephalosporins and penicillins in the treatment of group A beta-hemolytic streptococcal pharyngitis: a meta-analysis supporting the concept of microbial copathogenicity. Pediatr. Infect. Dis. J. 10 1991 275 281","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/00365549409008592","article-title":"Five versus ten days treatment of streptococcal pharyngotonsillitis: a randomized controlled trial comparing cefpodoxime proxetil and phenoxymethyl penicillin.","volume":"26","author":"Portier H.","year":"1994","unstructured":"Portier H. Chavanet P. Waldner A. Five versus ten days treatment of streptococcal pharyngotonsillitis: a randomized controlled trial comparing cefpodoxime proxetil and phenoxymethyl penicillin. Scand. J. Infect. Dis. 26 1994 59 66","journal-title":"Scand. J. Infect. Dis."},{"key":"e_1_3_2_13_2","unstructured":"Searle\n              S. R.\n          Linear models.\n          1971\n          John Wiley and Sons\n          New York N.Y"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00006454-199401000-00002","article-title":"Streptococcal pharyngitis: the case for penicillin therapy.","volume":"13","author":"Shulman S. T.","year":"1994","unstructured":"Shulman S. T. Gerber M. A. Tanz R. R. Markowitz M. Streptococcal pharyngitis: the case for penicillin therapy. Pediatr. Infect. Dis. J. 13 1994 1 7","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/00006454-198611000-00010","article-title":"Comparison of oral cephalosporins with penicillin therapy for group A streptococcal pharyngitis.","volume":"5","author":"Stillerman M.","year":"1986","unstructured":"Stillerman M. Comparison of oral cephalosporins with penicillin therapy for group A streptococcal pharyngitis. Pediatr. Infect. Dis. J. 5 1986 649 654","journal-title":"Pediatr. Infect. Dis. J."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.5.1073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.42.5.1073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:58:28Z","timestamp":1645480708000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.42.5.1073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1128\/AAC.42.5.1073"],"URL":"https:\/\/doi.org\/10.1128\/aac.42.5.1073","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]},"assertion":[{"value":"1997-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"1998-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}